Items where Author is "Ferguson, Michael A. J."

Journal Article

Wyllie, Susan and Thomas, Michael and Patterson, Stephen and Crouch, Sabrinia and De Rycker, Manu and Lowe, Rhiannon and Gresham, Stephanie and Urbaniak, Michael Daniel and Otto, Thomas D. and Stojanovski, Laste and Simeons, Frederick R. C. and Manthri, Sujatha and MacLean, Lorna M. and Zuccotto, Fabio and Homeyer, Nadine and Pflaumer, Hannah and Boesche, Markus and Sastry, Lalitha and Connolly, Paul and Albrecht, Sebastian and Berriman, Matt and Drewes, Gerard and Gray, David W. and Ghidelli-Disse, Sonja and Dixon, Susan and Fiandor, Jose M. and Wyatt, Paul G. and Ferguson, Michael A. J. and Fairlamb, Alan H. and Miles, Timothy J. and Read, Kevin D. and Gilbert, Ian H. (2018) Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis. Nature, 560. pp. 192-197. ISSN 0028-0836

Domingo Sananes, Maria Rosa and Szoor, Balazs and Ferguson, Michael A. J. and Urbaniak, Mick and Matthews, Keith R. (2015) Molecular control of irreversible bistability during trypanosome developmental commitment. Journal of Cell Biology, 211 (2). pp. 455-468. ISSN 0021-9525

Shameer, Sanu and Logan-Klumpler, Flora J. and Vinson, Florence and Cottret, Ludovic and Merlet, Benjamin and Achcar, Fiona and Boshart, Michael and Berriman, Matthew and Breitling, Rainer and Bringaud, Frédéric and Bütikofer, Peter and Cattanach, Amy M. and Bannerman-Chukualim, Bridget and Creek, Darren J. and Crouch, Kathryn and de Koning, Harry P. and Denise, Hubert and Ebikeme, Charles and Fairlamb, Alan H. and Ferguson, Michael A. J. and Ginger, Michael L. and Hertz-Fowler, Christiane and Kerkhoven, Eduard J. and Mäser, Pascal and Michels, Paul A. M. and Nayak, Archana and Nes, David W. and Nolan, Derek P. and Olsen, Christian and Silva-Franco, Fatima and Smith, Terry K. and Taylor, Martin C. and Tielens, Aloysius G. M. and Urbaniak, Michael D. and van Hellemond, Jaap J. and Vincent, Isabel M. and Wilkinson, Shane R. and Wyllie, Susan and Opperdoes, Fred R. and Barrett, Michael P. and Jourdan, Fabien (2015) TrypanoCyc : a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43 (D1). D637-D644. ISSN 0305-1048

Urbaniak, Michael D. and Capes, Amy S. and Crossman, Arthur and O'Neill, Sandra and Thompson, Stephen and Gilbert, Ian H. and Ferguson, Michael A. J. (2014) Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase. Carbohydrate Research, 387. pp. 54-58. ISSN 0008-6215

Güther, Maria Lucia S. and Urbaniak, Michael D. and Tavendale, Amy and Prescott, Alan and Ferguson, Michael A. J. (2014) High-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics. Journal of Proteome Research, 13 (6). pp. 2796-2806. ISSN 1535-3893

Capes, Amy S. and Crossman, Arthur and Urbaniak, Michael D. and Gilbert, Sophie H. and Ferguson, Michael A. J. and Gilbert, Ian H. (2014) Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues. Organic and Biomolecular Chemistry, 2014 (12). pp. 1919-1934. ISSN 1477-0520

Fang, Wenxia and Du, Ting and Raimi, Olawale G. and Hurtado-Guerrero, Ramon and Urbaniak, Mick and Ibrahim, Adel F. M. and Ferguson, Michael A. J. and van Aalten, Daan M. F. (2013) Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as a potential antifungal target. Molecular Microbiology, 89 (3). pp. 479-493. ISSN 0950-382X

Urbaniak, Michael and Ferguson, Michael A. J. and Martin, David M. A. (2013) Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei. Journal of Proteome Research, 12. pp. 2233-2244. ISSN 1535-3893

Urbaniak, Michael D. and Mathieson, Toby and Bantscheff, Marcus and Eberhard, Dirk and Grimaldi, Raffaella and Miranda-Saavedra, Diego and Wyatt, Paul and Ferguson, Michael A. J. and Frearson, Julie and Drewes, Gerard (2012) Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei. ACS Chemical Biology, 7 (11). pp. 1858-1865. ISSN 1554-8929

Urbaniak, Michael and Guther, M. Lucia S. and Ferguson, Michael A. J. (2012) Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages. PLoS ONE, 7 (5): e36619. ISSN 1932-6203

Abdelwahab, Nuha Z. and Urbaniak, Michael D. and Ferguson, Michael A. J. and Crossman, Arthur T. (2011) Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei. Carbohydrate Research, 346 (6). pp. 708-714. ISSN 0008-6215

Durrant, Jacob D. and Urbaniak, Michael D. and Ferguson, Michael A. J. and McCammon, J. Andrew (2010) Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors : toward the development of novel therapies for African sleeping sickness. Journal of Medicinal Chemistry, 53 (13). pp. 5025-5032. ISSN 1520-4804

Durrant, Jacob D. and Amaro, Rommie E. and Xie, Lei and Urbaniak, Michael D. and Ferguson, Michael A. J. and Haapalainen, Antti and Chen, Zhijun and Di Guilmi, Anne Marie and Wunder, Frank and Bourne, Philip E. and McCammon, J. Andrew (2010) A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology. PLoS Computational Biology, 6 (1): e1000648. ISSN 1553-7358

Urbaniak, Michael D. and Yashunsky, Dmitry V. and Crossman, Arthur and Nikolaev, Andrei V. and Ferguson, Michael A. J. (2008) Probing enzymes late in the trypanosomal glycosylphosphatidylinositol biosynthetic pathway with synthetic glycosylphosphatidylinositol analogues. ACS Chemical Biology, 3 (10). pp. 625-634. ISSN 1554-8929

Urbaniak, Michael D. and Crossman, Arthur and Ferguson, Michael A. J. (2008) Probing Trypanosoma brucei glycosylphosphatidylinositol biosynthesis using novel precursor-analogues. Chemical Biology and Drug Design, 72 (2). pp. 127-132. ISSN 1747-0277

Crossman, Arthur T. and Urbaniak, Michael D. and Ferguson, Michael A. J. (2008) Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate) : a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis. Carbohydrate Research, 343 (9). pp. 1478-1481. ISSN 0008-6215

Urbaniak, Michael D. and Tabudravu, Jioji N. and Msaki, Aichi and Matera, Kathy Mansfield and Brenk, Ruth and Jaspars, Marcel and Ferguson, Michael A. J. (2006) Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorganic and Medicinal Chemistry Letters, 16 (22). pp. 5744-5747. ISSN 0960-894X

Urbaniak, Michael D. and Turnock, Daniel C. and Ferguson, Michael A. J. (2006) Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4'-epimerase conditional null mutant. Eukaryotic Cell, 5 (11). pp. 1906-1913. ISSN 1535-9778

Alphey, Magnus S. and Burton, Andrew and Urbaniak, Michael D. and Boons, Geert-Jan and Ferguson, Michael A. J. and Hunter, William N. (2006) Trypanosoma brucei UDP-galactose-4'-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 62 (9). pp. 829-834.

Urbaniak, Michael D. and Crossman, Arthur and Chang, Tunhan and Smith, Terry K. and van Aalten, Daan M. F. and Ferguson, Michael A. J. (2005) The N-acetyl-D-glucosaminylphosphatidylinositol De-N-acetylase of glycosylphosphatidylinositol biosynthesis is a zinc metalloenzyme. Journal of Biological Chemistry, 280 (24). pp. 22831-22838. ISSN 0021-9258