Urbaniak, Michael D. and Tabudravu, Jioji N. and Msaki, Aichi and Matera, Kathy Mansfield and Brenk, Ruth and Jaspars, Marcel and Ferguson, Michael A. J. (2006) Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorganic and Medicinal Chemistry Letters, 16 (22). pp. 5744-5747. ISSN 0960-894X
Full text not available from this repository.Abstract
Novel inhibitors of Trypanosoma brucei and mammalian UDP-Glc 4'-epimerase were identified by screening a small library of natural products and commercially available drug-like molecules. The inhibitors possess low micromolar potency against the T. brucei and human enzymes in vitro, display a degree of selectivity between the two enzymes, and are cytotoxic to cultured T. brucei and mammalian cells.