Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei

Abdelwahab, Nuha Z. and Urbaniak, Michael D. and Ferguson, Michael A. J. and Crossman, Arthur T. (2011) Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei. Carbohydrate Research, 346 (6). pp. 708-714. ISSN 0008-6215

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Abstract

A small zinc-binding group (ZBG) library of deoxy-2-C-branched-monosaccharides, for example, 1,5-anhydroglucitols, consisting of either monodentate ligand binding carboxylic acids or bidentate ligand binding hydroxamic acids, were prepared to assess the zinc affinity of the putative metalloenzyme 2-acetamido-2-deoxy-α-D-glucopyranosyl-(1→6)-phosphatidylinositol de-N-acetylase (EC 3.5.1.89) of glycosylphosphatidylinositol biosynthesis. The N-ureido thioglucoside was also synthesised and added to the ZBG library because a previous N-ureido analogue, synthesised by us, had inhibitory activity against the aforementioned de-N-acetylase, presumably via the N-ureido motif.

Item Type: Journal Article
Journal or Publication Title: Carbohydrate Research
Additional Information: Copyright © 2011 Elsevier Ltd. All rights reserved.
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1600/1602
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 66388
Deposited By: ep_importer_pure
Deposited On: 17 Sep 2013 08:07
Refereed?: Yes
Published?: Published
Last Modified: 22 Feb 2020 02:17
URI: https://eprints.lancs.ac.uk/id/eprint/66388

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