Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei

Abdelwahab, Nuha Z. and Urbaniak, Michael D. and Ferguson, Michael A. J. and Crossman, Arthur T. (2011) Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei. Carbohydrate Research, 346 (6). pp. 708-714. ISSN 0008-6215

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Abstract

A small zinc-binding group (ZBG) library of deoxy-2-C-branched-monosaccharides, for example, 1,5-anhydroglucitols, consisting of either monodentate ligand binding carboxylic acids or bidentate ligand binding hydroxamic acids, were prepared to assess the zinc affinity of the putative metalloenzyme 2-acetamido-2-deoxy-α-D-glucopyranosyl-(1→6)-phosphatidylinositol de-N-acetylase (EC 3.5.1.89) of glycosylphosphatidylinositol biosynthesis. The N-ureido thioglucoside was also synthesised and added to the ZBG library because a previous N-ureido analogue, synthesised by us, had inhibitory activity against the aforementioned de-N-acetylase, presumably via the N-ureido motif.

Item Type:
Journal Article
Journal or Publication Title:
Carbohydrate Research
Additional Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1600/1602
Subjects:
ID Code:
66388
Deposited By:
Deposited On:
17 Sep 2013 08:07
Refereed?:
Yes
Published?:
Published
Last Modified:
09 Aug 2020 02:29