Items where Author is "Unterholzner, Leonie"

Journal Article

Scott, Andrew and Farrar, Benjamin and Young, Tom and Prior, Joann and Stratilo, Chad and Unterholzner, Leonie and D’Elia, Riccardo (2024) Single-stranded DNA oligonucleotides containing CpG motifs are non-stimulatory in vitro but offer protection in vivo against Burkholderia pseudomallei. Frontiers in cellular and infection microbiology, 14: 1458435. ISSN 2235-2988

Wheeler, Otto P G and Unterholzner, Leonie (2023) DNA sensing in cancer : Pro-tumour and anti-tumour functions of cGAS-STING signalling. Essays in Biochemistry, 67 (6). pp. 905-918. ISSN 0071-1365

Unterholzner, Leonie and Dunphy, Gillian (2019) cGAS-independent STING activation in response to DNA damage. Molecular & Cellular Oncology, 6 (4): e1558682. ISSN 2372-3556

Unterholzner, Leonie (2019) Beyond sensing DNA : A role for cGAS in the detection of extracellular cyclic di-nucleotides. EMBO Reports, 20 (4): e47970. ISSN 1469-221X

Unterholzner, Leonie and Almine, Jessica Frances (2019) Camouflage and interception : How pathogens evade detection by intracellular nucleic acid sensors. Immunology, 156 (3). pp. 217-227. ISSN 0019-2805

Dunphy, Gillian and Flannery, Sinead and Almine, Jessica and Connolly, Dympna and Paulus, Christina and Jønsson, Kasper and Jakobsen, Martin and Nevels, Michael and Bowie, Andrew and Unterholzner, Leonie (2018) Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-κB signalling after nuclear DNA damage. Molecular Cell, 71 (5). pp. 745-760. ISSN 1097-2765

Almine, Jessica F. and O'Hare, Craig A. J. and Dunphy, Gillian and Haga, Ismar R. and Naik, Rangeetha J. and Atrih, Abdelmadjid and Connolly, Dympna J. and Taylor, Jordan and Kelsall, Ian R. and Bowie, Andrew G. and Beard, Philippa M. and Unterholzner, Leonie (2017) IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes. Nature Communications, 8: 14392. ISSN 2041-1723

Unterholzner, Leonie (2013) The interferon response to intracellular DNA : why so many receptors? Immunobiology, 218 (11). pp. 1312-1321. ISSN 0171-2985

Horan, Kristy A. and Hansen, Kathrine and Jakobsen, Martin R. and Holm, Christian K. and Søby, Stine and Unterholzner, Leonie and Thompson, Mikayla and West, John A. and Iversen, Marie B. and Rasmussen, Simon B. and Ellermann-Eriksen, Svend and Kurt-Jones, Evelyn and Landolfo, Santo and Damania, Blossom and Melchjorsen, Jesper and Bowie, Andrew G. and Fitzgerald, Katherine A. and Paludan, Søren R. (2013) Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors. Journal of Immunology, 190 (5). pp. 2311-2319. ISSN 0022-1767

Mansur, Daniel S. and Maluquer de Motes, Carlos and Unterholzner, Leonie and Sumner, Rebecca P. and Ferguson, Brian J. and Ren, Hongwei and Strnadova, Pavla and Bowie, Andrew G. and Smith, Geoffrey L. (2013) Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry : a mechanism to inhibit NF-κB activation and promote immune evasion and virulence. PLoS Pathogens, 9 (2): e1003183. ISSN 1553-7366

Jin, Tengchuan and Perry, Andrew and Jiang, Jiansheng and Smith, Patrick and Curry, James A. and Unterholzner, Leonie and Jiang, Zhaozhao and Horvath, Gabor and Rathinam, Vijay A. and Johnstone, Ricky W. and Hornung, Veit and Latz, Eicke and Bowie, Andrew G. and Fitzgerald, Katherine A. and Xiao, T. Sam (2012) Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity, 36 (4). pp. 561-571. ISSN 1074-7613

Unterholzner, Leonie and Sumner, Rebecca P. and Baran, Marcin and Ren, Hongwei and Mansur, Daniel S. and Bourke, Nollaig M. and Randow, Felix and Smith, Geoffrey L. and Bowie, Andrew G. (2011) Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7. PLoS Pathogens, 7 (9): e1002247. ISSN 1553-7366

Unterholzner, Leonie and Bowie, Andrew G. (2011) Innate DNA sensing moves to the nucleus. Cell Host and Microbe, 9 (5). pp. 351-353. ISSN 1931-3128

Unterholzner, Leonie and Keating, Sinead E. and Baran, Marcin and Horan, Kristy A. and Jensen, Søren B. and Sharma, Shruti and Sirois, Cherilyn M. and Jin, Tengchuan and Latz, Eicke and Xiao, T. Sam and Fitzgerald, Katherine A. and Paludan, Søren R. and Bowie, Andrew G. (2010) IFI16 is an innate immune sensor for intracellular DNA. Nature Immunology, 11 (11). pp. 997-1004. ISSN 1529-2908

Bowie, Andrew G. and Unterholzner, Leonie (2008) Viral evasion and subversion of pattern-recognition receptor signalling. Nature Immunology, 8 (12). pp. 911-922. ISSN 1529-2908

Unterholzner, Leonie and Bowie, Andrew G. (2008) The interplay between viruses and innate immune signaling : recent insights and therapeutic opportunities. Biochemical Pharmacology, 75 (3). pp. 589-602. ISSN 0006-2952

Fukuhara, Noemi and Ebert, Judith and Unterholzner, Leonie and Lindner, Doris and Izaurralde, Elisa and Conti, Elena (2005) SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Molecular Cell, 17 (4). pp. 537-547. ISSN 1097-2765

Unterholzner, Leonie and Izaurralde, Elisa (2004) SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Molecular Cell, 16 (4). pp. 587-596. ISSN 1097-2765

Bono, Fulvia and Ebert, Judith and Unterholzner, Leonie and Güttler, Thomas and Izaurralde, Elisa and Conti, Elena (2004) Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. EMBO Reports, 5 (3). pp. 304-310. ISSN 1469-221X

Gatfield, David and Unterholzner, Leonie and Ciccarelli, Francesca D and Bork, Peer and Izaurralde, Elisa (2003) Nonsense-mediated mRNA decay in Drosophila : at the intersection of the yeast and mammalian pathways. EMBO Journal, 22 (15). pp. 3960-3970. ISSN 0261-4189

Contribution to Conference

Walker, Thomas and Unterholzner, Leonie (2024) Disparate STING signalling as a link between bladder cancer cell innate immune response and the immunostimulatory state of the tumour microenvironment following genotoxic therapies. In: Cancer Research UK: Cancer and the host - tumour immunology, 2024-05-07 - 2024-05-07, The Francis Crick Institute.

Walker, Thomas and Morris, Jessica and Unterholzner, Leonie (2024) Disparate STING signalling as a link between bladder cancer cell innate immune response and the immunostimulatory state of the tumour microenvironment following genotoxic therapies. In: TOLL 2024 Conference, 2024-04-17 - 2024-04-20, De Doelen Rotterdam.

Thesis

Slater, Tommy and Robinson, Nick and Unterholzner, Leonie (2029) A novel archaeal antiviral defence system and possible links to the origins of eukaryotic innate immunity. Masters thesis, Lancaster University.

Young, Tom and Unterholzner, Leonie (2025) Modulation of the Innate Immune System by Catalytically Inactive Single Stranded Oligonucleotides. PhD thesis, Lancaster University.

Clayton, Emily and Munir, Muhammad and Unterholzner, Leonie (2024) Investigating the Innate Immune Systems of Bats and Their Roles as Zoonotic Viral Reservoirs. PhD thesis, Lancaster University.

Khalifa, Manar and Munir, Muhammad and Unterholzner, Leonie (2023) Understanding Receptor-mediated Spillover of Rabies Virus Across Different Mammalian Hosts. PhD thesis, Biomedical and Life Sciences.

Kimble, Joshua and Unterholzner, Leonie and Jackson-Jones, Lucy (2023) How does dysregulation of DNA sensing cause the autoinflammatory syndrome SAVI? Masters thesis, Lancaster University.

Williams, Manon and Robinson, Nick and Unterholzner, Leonie (2023) Antiviral immunity in ancient archaea and possible origins of the progenitors of the eukaryotic innate immune system. Masters thesis, UNSPECIFIED.

Barker, Rebecca and Unterholzner, Leonie and Bates, Paul (2023) Investigation into the dysregulation of pattern recognition receptor signalling in Leishmania mexicana infected THP-1 cells. PhD thesis, Lancaster University.

Bayoumi, Mahmoud and Munir, Muhammad and Unterholzner, Leonie (2023) Understanding the Replication Kinetics of Influenza A Viruses under Chicken N6-methyladenosine (m6A) Epitranscriptomic Pressure. PhD thesis, Lancaster University.

Dowling, Aaron and Unterholzner, Leonie (2018) How does Vaccinia virus inhibit the detection of cytosolic DNA by the innate Immune system? PhD thesis, Lancaster University.

Dunphy, Gillian and Unterholzner, Leonie (2017) The cell-intrinsic innate immune response to DNA damage in human cells. PhD thesis, Lancaster University.

O'Hare, Craig and Unterholzner, Leonie (2017) An examination of the role of IFI16 in detecting viral DNA in human immortalised keratinocytes. PhD thesis, Lancaster University.