cGAS-independent STING activation in response to DNA damage

Unterholzner, Leonie and Dunphy, Gillian (2019) cGAS-independent STING activation in response to DNA damage. Molecular & Cellular Oncology, 6 (4). ISSN 2372-3556

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Abstract

Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes).

Item Type: Journal Article
Journal or Publication Title: Molecular & Cellular Oncology
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2400
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 134430
Deposited By: ep_importer_pure
Deposited On: 22 Jun 2019 08:52
Refereed?: Yes
Published?: Published
Last Modified: 13 Sep 2019 02:59
URI: https://eprints.lancs.ac.uk/id/eprint/134430

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