Beyond sensing DNA:A role for cGAS in the detection of extracellular cyclic di-nucleotides

Unterholzner, Leonie (2019) Beyond sensing DNA:A role for cGAS in the detection of extracellular cyclic di-nucleotides. EMBO Reports, 20 (4). ISSN 1469-221X

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Cyclic GMP-AMP synthase (cGAS) is best known as an innate immune receptor that detects pathogen DNA in the cytosol. In this issue of EMBO Reports, Kaufmann and colleagues report that cGAS has an additional role in innate immunity: It can also bind cyclic di-nucleotides (CDNs), signalling molecules produced by bacteria. The authors show that when extracellular CDNs are taken up by endocytosis, they bind to cGAS, causing it to form a complex with the CDN receptor STING (STimulator of INterferon Genes), thereby enhancing its activation. As cGAS is dispensable for the detection of intracellular CDNs, this work exemplifies how the localisation of pathogen-associated molecular patterns (PAMPs) influences innate immune signalling.

Item Type: Journal Article
Journal or Publication Title: EMBO Reports
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1300/1312
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 131957
Deposited By: ep_importer_pure
Deposited On: 28 Mar 2019 15:05
Refereed?: No
Published?: Published
Last Modified: 13 Sep 2019 03:04

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