Transcription stress causes an inflammatory response via release of IL-1α

Walker, Thomas D. J. and Morris, Jessica P. and Unterholzner, Leonie (2025) Transcription stress causes an inflammatory response via release of IL-1α. Nature Structural and Molecular Biology, 32 (4): 14756. pp. 591-594. ISSN 1545-9993

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Abstract

DNA damage can be sensed as a danger signal by the innate immune system. Bournique et al. show that the transcription stress caused by DNA lesions can also initiate inflammation by causing the direct release of cytokine IL-1α, which then drives NF-κB activation in neighboring cells.