Items where Author is "Holscher, Christian"

Journal Article

Salles, Geisa Nogueira and Pereira, Fernanda Aparecida dos Santos and Pacheco-Soares, Cristina and Marciano, Fernanda Roberta and Holscher, Christian and Webster, Thomas J. and Lobo, Anderson Oliveira (2017) A novel bioresorbable device as a controlled release system for protecting cells from oxidative stress from Alzheimer’s Disease. Molecular Neurobiology, 54 (9). pp. 6827-6838. ISSN 0893-7648

Jin, Qian-Qian and Sun, Jun-Hong and Du, Qiu-Xiang and Lu, Xiao-Jun and Zhu, Xi-Yan and Fan, Hao-Liang and Holscher, Christian and Wang, Ying-Yuan (2017) Integrating microRNA and messenger RNA expression profiles in a rat model of deep vein thrombosis. International Journal of Molecular Medicine, 40 (4). pp. 1019-1028. ISSN 1107-3756

Li, Yanwei and Zhao, Jinying and Holscher, Christian (2017) Therapeutic Potential of Baicalein in Alzheimer's Disease and Parkinson's Disease. CNS Drugs, 31 (8). pp. 639-652. ISSN 1172-7047

Li, Yanwei and Liu, WeiZhen and Li, Lin and Holscher, Christian (2017) D-Ala2-GIP-glu-PAL is neuroprotective in a chronic Parkinson's disease mouse model and increases BNDF expression while reducing neuroinflammation and lipid peroxidation. European Journal of Pharmacology, 797. pp. 162-172. ISSN 0014-2999

Cai, Hong-Yan and Wang, Zhao-Jun and Holscher, Christian and Yuan, Li and Zhang, Jun and Sun, Peng and Li, Jing and Yang, Wei and Wu, Mei-Na and Qi, Jin-Shun (2017) Lixisenatide attenuates the detrimental effects of amyloid β protein on spatial working memory and hippocampal neurons in rats. Behavioural Brain Research, 318. pp. 28-35. ISSN 0166-4328

Du, Yan and Du, Li and Cao, Jie and Holscher, Christian and Feng, Yongming and Su, Hongliang and Wang, Yujin and Yun, Ke-Ming (2017) Levo-tetrahydropalmatine inhibits the acquisition of ketamine-induced conditioned place preference by regulating the expression of ERK and CREB phosphorylation in rats. Behavioural Brain Research, 317. pp. 367-373. ISSN 0166-4328

Zhang, Peng and Holscher, Christian and Ma, Xun (2017) Therapeutic potential of flavonoids in spinal cord injury. Reviews in the Neurosciences, 28 (1). pp. 87-101. ISSN 0334-1763

Li, Yanwei and Li, Lin and Holscher, Christian (2016) Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases. Reviews in the Neurosciences, 27 (7). pp. 689-711. ISSN 0334-1763

Jalewa, Jaishree and Sharma, Mohit Kumar and Holscher, Christian (2016) Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells. Journal of Neurochemistry, 139 (1). pp. 55-67. ISSN 0022-3042

Li, Yanwei and Li, Lin and Holscher, Christian (2016) Therapeutic potential of genipin in central neurodegenerative diseases. CNS Drugs, 30 (10). pp. 889-897. ISSN 1172-7047

Lijun, Cao and Li, Dongfang and Feng, Peng and Li, Lin and Xue, Guofang and Li, Guanglai and Holscher, Christian (2016) A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson’s disease by reducing chronic inflammation in the brain. NeuroReport, 27 (6). pp. 384-391. ISSN 0959-4965

Olmos-Alonso, Adrian and Schetters, Sjoerd T. T. and Sri, Sarmi and Askew, Katharine and Mancuso, Renzo and Vargas-Caballero, Mariana and Holscher, Christian and Perry, V. Hugh and Gomez-Nicola, Diego (2016) Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology. Brain, 139 (3). pp. 891-907. ISSN 0006-8950

Ji, Chenhui and Xue, Guo-Fang and Lijun, Cao and Feng, Peng and Li, Dongfang and Li, Lin and Li, Guanglai and Holscher, Christian (2016) A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson′s disease by increasing expression of BNDF. Brain Research, 1634. pp. 1-11. ISSN 0006-8993

Pan, Xiaobei and Nasaruddin, Muhammad Bin and Elliott, Christopher T. and McGuinness, Bernadette and Passmore, Anthony Peter and Kehoe, Patrick G. and Holscher, Christian and McClean, Paula L and Graham, Stewart F. and Green, Brian D. (2016) Alzheimer's disease–like pathology has transient effects on the brain and blood metabolome. Neurobiology of Aging, 38. pp. 151-163. ISSN 0197-4580

Li, Yanwei and Liu, WeiZhen and Li, Lin and Holscher, Christian (2016) Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model. Neuropharmacology, 101. pp. 255-263. ISSN 0028-3908

Nasaruddin, Muhammad Luqman and Holscher, Christian and Kehoe, Patrick and Graham, Stewart F. and Green, Brian (2016) Wide-ranging alterations in the brain fatty acid complement of subjects with late Alzheimer’s disease as detected by GC-MS. American Journal of Translational Research, 8 (1). pp. 154-165. ISSN 1943-8141

Han, Ling and Holscher, Christian and Xue, Guofang and Li, Guanglai and Li, Dongfang (2016) A novel dual-glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist is neuroprotective in transient focal cerebral ischemia in the rat. NeuroReport, 27 (1). pp. 23-32. ISSN 0959-4965

Ji, Chenhui and Xue, Guo-Fang and Li, Guanglai and Li, Dongfang and Holscher, Christian (2016) Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's disease. Reviews in the Neurosciences, 27 (1). pp. 61-70. ISSN 0334-1763

Li, Lin and Liu, Ke and Holscher, Christian and Li, Guanglai and Liu, Yue-Ze (2016) Neuroprotective role of (Val8)GLP-1-Glu-PAL in an in vitro model of Parkinson’s disease. Neural Regeneration Research, 11 (2). pp. 326-331. ISSN 1673-5374

Chen, YiMei and Zhang, YanFang and Li, Lin and Holscher, Christian (2015) Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease. European Journal of Pharmacology, 768. pp. 21-27. ISSN 0014-2999

Zhang, YanFang and Chen, YiMei and Li, Lin and Holscher, Christian (2015) Neuroprotective effects of (Val8)GLP-1-Glu-PAL in the MPTP Parkinson's disease mouse model. Behavioural Brain Research, 293. pp. 107-113. ISSN 0166-4328

McClean, Paula L. and Jalewa, Jaishree and Holscher, Christian (2015) Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice. Behavioural Brain Research, 293. pp. 96-106. ISSN 0166-4328

Liu, W. and Jalewa, Jaishree and Sharma, Mohit and Li, G. and Li, L. and Holscher, Christian (2015) Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Neuroscience, 303. pp. 42-50. ISSN 0306-4522

Liu, WeiZhen and Li, Guanglai and Holscher, Christian and Li, Lin (2015) Neuroprotective effects of geniposide on Alzheimer's disease pathology. Reviews in the Neurosciences, 26 (4). pp. 371-383. ISSN 0334-1763

Graham, Stewart F. and Chevallier, Olivier P. and Elliott, Christopher T. and Holscher, Christian and Johnston, Janet and McGuinness, Bernadette and Kehoe, Patrick G. and Passmore, Anthony Peter and Green, Brian D. (2015) Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease. PLoS ONE, 10 (3): e0119452. ISSN 1932-6203

Kelly, Patricia and McClean, Paula L. and Ackermann, Maximilian and Konerding, Moritz A. and Holscher, Christian and Mitchell, Christopher A. (2015) Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with Liraglutide™. Microcirculation, 22 (2). pp. 133-145. ISSN 1549-8719

Graham, Stewart F. and Nasarauddin, Muhammad Bin and Carey, Manus and McGuinness, Bernadette and Holscher, Christian and Kehoe, Patrick G. and Love, Seth and Passmore, Anthony P. and Elliott, Christopher T. and Meharg, Andrew and Green, Brian D. (2015) Quantitative measurement of [Na+] and [K+] in postmortem human brain tissue indicates disturbances in subjects with Alzheimer's Disease and dementia with Lewy bodies. Journal of Alzheimer's Disease, 44 (3). pp. 851-857. ISSN 1387-2877

Lennox, Rachael and Porter, David W. and Flatt, Peter R. and Holscher, Christian and Irwin, Nigel and Gault, Victor A. (2014) Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice. Neuropharmacology, 86. pp. 22-30. ISSN 0028-3908

McClean, Paula L. and Holscher, Christian (2014) Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease. Neuropharmacology, 86. pp. 241-258. ISSN 0028-3908

Graham, Stewart F. and Holscher, Christian and Green, Brian D. (2014) Metabolic signatures of human Alzheimer's disease (AD) : H-1 NMR analysis of the polar metabolome of post-mortem brain tissue. Metabolomics, 10 (4). pp. 744-753. ISSN 1573-3882

Holscher, Christian (2014) Peptide drugs that have been developed to treat type 2 diabetes show neuroprotective effects. Regulatory Peptides, 192-19. pp. 55-56. ISSN 1873-1686

Holscher, Christian (2014) Central effects of GLP-1 : new opportunities for treatments of neurodegenerative diseases. Journal of Endocrinology, 221. T31-T41. ISSN 1479-6805

Graham, Stewart F. and Nasaruddin, Muhammad Bin and Carey, Manus and Holscher, Christian and McGuinness, Bernadette and Kehoe, Patrick G. and Love, Seth and Passmore, Peter and Elliott, Christopher T. and Meharg, Andrew A. and Green, Brian D. (2014) Age-associated changes of brain copper, iron, and zinc in Alzheimer's disease and dementia with Lewy bodies. Journal of Alzheimer's Disease, 42 (4). pp. 1407-1413. ISSN 1387-2877

Lourenco, Mychael V. and Clarke, Julia R. and Frozza, Rudimar L. and Bomfim, Theresa R. and Forny-Germano, Letícia and Batista, André F. and Sathler, Luciana B. and Brito-Moreira, Jordano and Amaral, Olavo B. and Silva, Cesar A. and Freitas-Correa, Léo and Espírito-Santo, Sheila and Campello-Costa, Paula and Houzel, Jean-Christophe and Klein, William L. and Holscher, Christian and Carvalheira, José B. and Silva, Aristobolo M. and Velloso, Lício A. and Munoz, Douglas P. and Ferreira, Sergio T. and De Felice, Fernanda G. (2013) TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-Amyloid oligomers in mice and monkeys. Cell Metabolism, 18 (6). pp. 831-843. ISSN 1932-7420

Graham, Stewart F. and Holscher, Christian and McClean, Paula and Elliot, Christopher T and Green, Brian D. (2013) H-1 NMR metabolomics investigation of an Alzheimer's disease (AD) mouse model pinpoints important biochemical disturbances in brain and plasma. Metabolomics, 9 (5). pp. 974-983. ISSN 1573-3890

Freiherr, Jessica and Hallschmid, Manfred and Frey, William and Brünner, Yvonne and Chapman, Colin and Holscher, Christian and Craft, Suzanne and De Felice, Fernanda and Benedict, Christian (2013) Intranasal insulin as a treatment for Alzheimer’s Disease : a review of basic research and clinical evidence. CNS Drugs, 27 (7). pp. 505-514. ISSN 1179-1934

Faivre, Emilie and Holscher, Christian (2013) Neuroprotective effects of D-Ala2GIP on Alzheimer’s disease biomarkers in an APP/PS1 mouse model. Alzheimer's Research and Therapy, 5: 20. pp. 20-29.

Faivre, Emilie and Holscher, Christian (2013) D-Ala2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer’s disease mouse model. Journal of Alzheimer's Disease, 35 (2). pp. 267-283. ISSN 1387-2877

Parthsarathy, Vadivel and Holscher, Christian (2013) Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model. PLoS ONE, 8 (3): e58784. ISSN 1932-6203

Gault, Victor and Lennox, R. and Porter, David and Holscher, Christian and Flatt, Peter (2013) Beneficial actions of glucagon-like peptide 1 (GLP-1) on hippocampal synaptic plasticity, gene expression, oxidative stress and inflammation in mice with diet-induced obesity and insulin resistance. Diabetic Medicine, 30 (Supple): A9 (P99). p. 4. ISSN 0742-3071

Long-Smith, Caitriona M. and Manning, Sean and McClean, Paula L. and Coakley, Meghan F. and O'Halloran, Domhnall J. and Holscher, Christian and O'Neill, Cora (2013) The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease. NeuroMolecular Medicine, 15 (1). pp. 102-114. ISSN 1559-1174

McClean, Paula L. and Holscher, Christian (2013) Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer ‘s disease. Neuropharmacology, 76 (Part A). pp. 57-67. ISSN 0028-3908

Holscher, Christian (2012) Potential roles of glucagon-like peptide-1 (GLP-1) in neuroprotection. CNS Drugs, 26 (10). pp. 871-882. ISSN 1179-1934

Hamilton, Alison and Holscher, Christian (2012) The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease. Brain Research, 1449. pp. 83-93. ISSN 0006-8993

Bomfim, Theresa R. and Forny-Germano, Leticia and Sathler, Luciana B. and Brito-Moreira, Jordano and Houzel, Jean-Christophe and Decker, Helena and Silverman, Michael A. and Kazi, Hala and Melo, Helen M. and McClean, Paula L. and Holscher, Christian and Arnold, Steven E. and Talbot, Konrad and Klein, William L. and Munoz, Douglas P. and Ferreira, Sergio T. and De Felice, Fernanda G. (2012) An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers. Journal of Clinical Investigation, 122 (4). pp. 1339-1353. ISSN 1558-8238

Gengler, Simon and McClean, Paula L. and McCurtin, Ruth and Gault, Victor A. and Holscher, Christian (2012) Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiology of Aging, 33 (2). pp. 265-276. ISSN 0197-4580

Hunter, Kerry and Holscher, Christian (2012) Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis. BMC Neuroscience, 13. pp. 33-38. ISSN 1471-2202

Holscher, Christian (2011) Diabetes as a risk factor for Alzheimer’s disease : insulin signalling impairment in the brain as an alternative model of Alzheimer’s disease. Biochemical Society Transactions, 39 (4). pp. 891-897. ISSN 0300-5127

McClean, Paula L. and Parthsarathy, Vadivel and Faivre, Emilie and Holscher, Christian (2011) The diabetes drug Liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. Journal of Neuroscience, 31 (17). pp. 6587-6594. ISSN 0270-6474

Gault, V. A. and Porter, W. D. and Flatt, P. R. and Holscher, Christian (2010) Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet. International Journal of Obesity, 34. pp. 1341-1344. ISSN 0307-0565

Gengler, Simon and Hamilton, A. and Holscher, Christian (2010) Synaptic plasticity in the hippocampus of an APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice. PLoS ONE, 5 (3): e9764. ISSN 1932-6203

Thesis

Panagaki, Theodora and Holscher, Christian (2018) Neuroprotective effects of incretin mimetics upon chronic endoplasmic reticulum (ER) stress : implications for novel therapeutic pathways and opportunities in Alzheimer's disease. PhD thesis, Lancaster University.

Michael, Maria and Allsop, David and Holscher, Christian (2017) A study investigating the blood-brain barrier penetration, distribution and elimination of retro-inverso peptides as candidate treatments for Alzheimer’s disease. PhD thesis, Lancaster University.