Items where Author is "Hölscher, Christian"

Reich, Niklas and Hölscher, Christian (2022) The neuroprotective effects of glucagon-like peptide 1 in Alzheimer’s and Parkinson’s disease: An in-depth review. Frontiers in Neuroscience, 16: 970925. ISSN 1662-453X

Coutrot, Antoine and Manley, Ed and Goodroe, Sarah and Gahnstrom, Christoffer and Filomena, Gabriele and Yesiltepe, Demet and Conroy-Dalton, Ruth and Wiener, Jan M. and Hölscher, Christian and Hornberger, Michael and Spiers, H. J. (2022) Entropy of city street networks linked to future spatial navigation ability. Nature, 604 (7904). 104–110. ISSN 0028-0836

Reich, Niklas and Hölscher, Christian (2020) Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease. Frontiers in Neuroscience, 14: 614828. ISSN 1662-453X

Wang, Li and Zhang, Rui and Hou, Xiaohong and Wang, Changtu and Guo, Shuai and Ning, Na and Sun, Cong and Yuan, Yuan and Li, Lin and Hölscher, Christian and Wang, Xiaohui (2019) DA-JC1 improves learning and memory by antagonizing Aβ31-35-induced circadian rhythm disorder. Molecular Brain, 12 (1): 12. ISSN 1756-6606

Salles, Geisa Nogueira and Calió, M.L. and Afewerki, S. and Pacheco-Soares, C. and Porcionatto, M. and Hölscher, Christian and Lobo, Anderson O. (2018) Prolonged Drug-Releasing Fibers Attenuate Alzheimer's Disease-like Pathogenesis. ACS Applied Materials and Interfaces, 10 (43). pp. 36693-36702. ISSN 1944-8244

Zhang, Liping and Zhang, Lingyu and Li, Lin and Hölscher, Christian (2018) Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model. Neuropeptides, 71. pp. 70-80. ISSN 0143-4179

Weina, Han and Yuhu, Niu and Hölscher, Christian and Birong, Li and Feiyu, Shen and Le, Wang (2018) Liraglutide Attenuates the Depressive- and Anxiety-like Behaviour in the Corticosterone Induced Depression Model Via Improving Hippocampal Neural Plasticity. Brain Research, 1694. pp. 55-62. ISSN 0006-8993

Hölscher, Christian and De Felice, Fernanda G. and Greig, Nigel and Ferreira, Sergio T. (2018) Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones? Neuropharmacology, 136 (Part B). p. 159. ISSN 0028-3908

Hölscher, Christian (2018) Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models. Neuropharmacology, 136 (Part B). pp. 251-259. ISSN 0028-3908

Cao, Yue and Hölscher, Christian and Hu, Meng-Ming and Wang, Ting and Zhao, Fang and Bai, Yu and Zhang, Jun and Wu, Mei-Na and Qi, Jin-Shun (2018) DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease. European Journal of Pharmacology, 827. pp. 215-226. ISSN 0014-2999

Feng, Peng and Zhang, Xiangjian and Li, Dongfang and Ji, Chenhui and Yuan, Ziyue and Wang, Ruifang and Xue, Guofang and Li, Guanglai and Hölscher, Christian (2018) Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease. Neuropharmacology, 133. pp. 385-394. ISSN 0028-3908

Wang, Rui-Fang and Xue, Guo-Fang and Hölscher, Christian and Tian, Miao-Jing and Feng, Peng and Zheng, Ji-Ying and Li, Dong-Fang (2018) Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus. Epilepsy Research, 142. pp. 45-52. ISSN 0920-1211

Gault, Victor A. and Hölscher, Christian (2018) GLP-1 receptor agonists show neuroprotective effects in animal models of diabetes. Peptides, 100. pp. 101-107. ISSN 0196-9781

Tai, Jingjing and Liu, Weizhen and Li, Yanwei and Li, Lin and Hölscher, Christian (2018) Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease. Brain Research, 1678. pp. 64-74. ISSN 0006-8993

Panagaki, Theodora and Michael, Maria and Hölscher, Christian (2017) Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells. Scientific Reports, 7: 16158. ISSN 2045-2322

Yuan, Ziyue and Li, Dongfang and Feng, Peng and Xue, Guofang and Ji, Chenhui and Li, Guanglai and Hölscher, Christian (2017) A novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson's disease. European Journal of Pharmacology, 812. pp. 82-90. ISSN 0014-2999

Shi, Lijuan and Zhang, Zhihua and Hölscher, Christian (2017) A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model. Behavioural Brain Research, 327. pp. 65-74. ISSN 0166-4328

Jalewa, Jaishree and Sharma, Mohit Kumar and Gengler, Simon and Hölscher, Christian (2017) A novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson's disease. Neuropharmacology, 117. pp. 238-248. ISSN 0028-3908

Jiao, Juan-Juan and Hölscher, Christian and Li, Tian and Dong, Xue-Fan and Qu, Xue-Song and Cao, Yue and Wu, Mei-Na and Wang, Zhao-Jun and Qi, Jin-Shun (2017) GLP-1/GIP/Gcg三受体激动剂改善3xTg-AD小鼠认知行为和病理特征研究. Acta Physiologica Sinica, 69 (2). pp. 135-145. ISSN 0371-0874

Hölscher, Christian (2016) Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide analogues as novel treatments for Alzheimer's and Parkinson's disease. Cardiovascular Endocrinology, 5 (3). pp. 93-98. ISSN 2162-688X

Han, Y.-F. and Hölscher, Christian and Wang, Z.-J. and Zhang, J. and Yuan, L. and Tong, J.-Q. and Wang, D.-D. and Wu, M.-N. and Qi, J.-S. (2016) 抗糖尿病新药(D-Ser2)Oxm 拮抗淀粉样β 蛋白细胞毒性的神经保护 效应观察. Acta Physiologica Sinica, 68 (3). pp. 265-275. ISSN 0371-0874

Liu, WeiZhen and Li, Yanwei and Jalewa, Jaishree and Saunders-Wood, Taylor and Li, Lin and Hölscher, Christian (2015) Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease. European Journal of Pharmacology, 765. pp. 284-290. ISSN 0014-2999

Cai, H.-Y. and Hölscher, Christian and Yue, X.-H. and Zhang, S.-X. and Wang, X.-H. and Qiao, F. and Yang, W. and Qi, J.-S. (2014) Lixisenatide rescues spatial memory and synaptic plasticity from amyloid β protein-induced impairments in rats. Neuroscience, 277. pp. 6-13. ISSN 0306-4522

Hölscher, Christian (2014) Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases. Biochemical Society Transactions, 42 (2). pp. 593-599. ISSN 0300-5127

Jalewa, Jaishree and Joshi, Alok and McGinnity, T. Martin and Prasad, Girijesh and Wong-Lin, KongFatt and Hölscher, Christian (2014) Neural circuit interactions between the dorsal raphe nucleus and the lateral hypothalamus : an experimental and computational study. PLoS ONE, 9 (2): e88003. ISSN 1932-6203

Hölscher, Christian (2014) First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease. Alzheimer's and Dementia, 10 (1 Supp). S33-37. ISSN 1552-5260

Sharma, Mohit and Jalewa, Jaishree and Hölscher, Christian (2014) Neuroprotective and anti-apoptotic effects of Liraglutide on SH-SY5Y cells exposed to Methylglyoxal stress. Journal of Neurochemistry, 128 (3). pp. 459-471. ISSN 0022-3042

Hölscher, Christian (2014) The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease. Alzheimer's and Dementia, 10 (1 Supp). S47-54. ISSN 1552-5260

Gao, Chong and Liu, Yueze and Li, Lin and Hölscher, Christian (2013) New animal models of Alzheimer's disease that display insulin desensitization in the brain. Reviews in the Neurosciences, 24 (6). pp. 607-615. ISSN 0334-1763

Porter, W. D. and Flatt, P. R. and Hölscher, Christian and Gault, Victor A. (2013) Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice. International Journal of Obesity, 37 (5). pp. 678-684. ISSN 0307-0565

Wang, Xiao-Hui and Yang, Wei and Hölscher, Christian and Wang, Zhao-Jun and Cai, Hong-Yan and Li, Qing-Shan and Qi, Jin-Shun (2013) Val⁸-GLP-1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid β peptide in rats. Journal of Neuroscience Research, 91 (4). pp. 568-577. ISSN 0360-4012

Graham, Stewart F. and Chevallier, Olivier P. and Roberts, Dominic and Hölscher, Christian and Elliott, Christopher T. and Green, Brian D. (2013) Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer's disease. Analytical Chemistry, 85 (3). pp. 1803-1811. ISSN 0003-2700

Han, Wei-Na and Hölscher, Christian and Yuan, Li and Yang, Wei and Wang, Xiao-Hui and Wu, Mei-Na and Qi, Jin-Shun (2013) Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats. Neurobiology of Aging, 34 (2). pp. 576-588. ISSN 0197-4580

Parthsarathy, Vadivel and Hölscher, Christian (2013) The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain. European Journal of Pharmacology, 700 (1-3). pp. 42-50. ISSN 0014-2999

Duffy, A. M. and Hölscher, Christian (2013) The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease. Neuroscience, 228. pp. 294-300. ISSN 0306-4522

Parthsarathy, Vadivel and McClean, Paula L and Hölscher, Christian and Taylor, Mark and Tinker, Claire and Jones, Glynn and Kolosov, Oleg and Salvati, Elisa and Gregori, Maria and Masserini, Massimo and Allsop, David (2013) A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1ΔE9 mouse model of Alzheimer's Disease. PLoS ONE, 8 (1): e54769. ISSN 1932-6203

McGovern, Stephen F. J. and Hunter, Kerry and Hölscher, Christian (2012) Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain. Brain Research, 1473. pp. 204-213. ISSN 0006-8993

Gao, Chong and Hölscher, Christian and Liu, Yueze and Li, Lin (2012) GSK3 : a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease. Reviews in the Neurosciences, 23 (1). pp. 1-11. ISSN 0334-1763

Faivre, Emilie and Hamilton, Alison and Hölscher, Christian (2012) Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice. European Journal of Pharmacology, 674 (2-3). pp. 294-306. ISSN 0014-2999

Li, Lin and Zhang, Zhi-Feng and Hölscher, Christian and Gao, Chong and Jiang, Yuan-Hong and Liu, Yue-Ze (2012) (Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. European Journal of Pharmacology, 674 (2-3). pp. 280-286. ISSN 0014-2999

Li, Lin and Hölscher, Christian and Chen, Bing-Bing and Zhang, Zhi-Feng and Liu, Yue-Ze (2011) Hepcidin treatment modulates the expression of divalent metal transporter-1, ceruloplasmin, and ferroportin-1 in the rat cerebral cortex and hippocampus. Biological Trace Element Research, 143 (3). pp. 1581-1593. ISSN 1559-0720

Faivre, Emilie and Gault, Victor A. and Thorens, Bernard and Hölscher, Christian (2011) Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis. Journal of Neurophysiology, 105 (4). pp. 1574-1580. ISSN 1522-1598

Hamilton, A. and Patterson, S. and Porter, David and Gault, Victor A. and Hölscher, Christian (2011) Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain. Journal of Neuroscience Research, 89 (4). pp. 481-489. ISSN 0360-4012

Porter, David W. and Irwin, Nigel and Flatt, Peter R. and Hölscher, Christian and Gault, Victor A. (2011) Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice. European Journal of Pharmacology, 650 (2-3). pp. 688-693. ISSN 0014-2999

Porter, D. W. and Kerr, B. D. and Flatt, P. R. and Hölscher, Christian and Gault, V. A. (2010) Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance. Diabetes, Obesity and Metabolism, 12 (10). pp. 891-899. ISSN 1463-1326

Hölscher, Christian (2010) Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease. Recent Patents on CNS Drug Discovery, 5 (2). pp. 109-117. ISSN 2212-3954

McClean, Paula L. and Gault, Victor A. and Harriott, Patrick and Hölscher, Christian (2010) Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain : a link between diabetes and Alzheimer's disease. European Journal of Pharmacology, 630 (1-3). pp. 158-162. ISSN 0014-2999

Fendt, M. and Bürki, H. and Imobersteg, S. and van der Putten, H. and McAllister, K. and Leslie, J. C. and Shaw, D. and Hölscher, Christian (2010) The effect of mGlu8 deficiency in animal models of psychiatric diseases. Genes, Brain and Behavior, 9 (1). pp. 33-44. ISSN 1601-183X

Hölscher, Christian (2010) The role of GLP-1 in neuronal activity and neurodegeneration. Vitamins and Hormones, 84. pp. 331-354. ISSN 0083-6729

Hamilton, Alison and Hölscher, Christian (2009) Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system. NeuroReport, 20 (13). pp. 1161-1166. ISSN 0959-4965