Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain:a link between diabetes and Alzheimer's disease

McClean, Paula L. and Gault, Victor A. and Harriott, Patrick and Hölscher, Christian (2010) Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain:a link between diabetes and Alzheimer's disease. European Journal of Pharmacology, 630 (1-3). pp. 158-162. ISSN 0014-2999

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Abstract

Type 2 diabetes has been identified as a risk factor for patients with Alzheimer's disease. Insulin signalling is often impaired in Alzheimer's disease, contributing to the neurodegenerative process. One potential strategy to help prevent this is the normalisation of insulin signalling in the brain. Therefore, the present study was designed to test the effects of novel enzyme-resistant analogues of the insulin-releasing incretin hormone, glucagon-like peptide 1 (GLP-1). The effects of Liraglutide (Victoza) and other novel GLP-1 analogues were tested on synaptic plasticity (LTP) in area CA1 of the hippocampus. At a dose of 15nmol in 5microl i.c.v., Liraglutide (P

Item Type:
Journal Article
Journal or Publication Title:
European Journal of Pharmacology
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3000/3004
Subjects:
ID Code:
69068
Deposited By:
Deposited On:
04 Apr 2014 10:05
Refereed?:
Yes
Published?:
Published
Last Modified:
20 May 2020 03:19