Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis

Faivre, Emilie and Gault, Victor A. and Thorens, Bernard and Hölscher, Christian (2011) Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis. Journal of Neurophysiology, 105 (4). pp. 1574-1580. ISSN 1522-1598

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Abstract

Glucose-dependent insulinotropic polypeptide (GIP) is a key incretin hormone, released from intestine after a meal, producing a glucose-dependent insulin secretion. The GIP receptor (GIPR) is expressed on pyramidal neurons in the cortex and hippocampus, and GIP is synthesized in a subset of neurons in the brain. However, the role of the GIPR in neuronal signaling is not clear. In this study, we used a mouse strain with GIPR gene deletion (GIPR KO) to elucidate the role of the GIPR in neuronal communication and brain function. Compared with C57BL/6 control mice, GIPR KO mice displayed higher locomotor activity in an open-field task. Impairment of recognition and spatial learning and memory of GIPR KO mice were found in the object recognition task and a spatial water maze task, respectively. In an object location task, no impairment was found. GIPR KO mice also showed impaired synaptic plasticity in paired-pulse facilitation and a block of long-term potentiation in area CA1 of the hippocampus. Moreover, a large decrease in the number of neuronal progenitor cells was found in the dentate gyrus of transgenic mice, although the numbers of young neurons was not changed. Together the results suggest that GIP receptors play an important role in cognition, neurotransmission, and cell proliferation.

Item Type: Journal Article
Journal or Publication Title: Journal of Neurophysiology
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1300/1314
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 69063
Deposited By: ep_importer_pure
Deposited On: 04 Apr 2014 10:55
Refereed?: Yes
Published?: Published
Last Modified: 19 Feb 2020 08:17
URI: https://eprints.lancs.ac.uk/id/eprint/69063

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