Alterations in the coupling functions between cortical and cardio-respiratory oscillations due to anæsthesia with propofol and sevoflurane

Stankovski, Tomislav and Petkoski, Spase and Raeder, Johan and Smith, Andrew and McClintock, Peter Vaughan Elsmere and Stefanovska, Aneta (2016) Alterations in the coupling functions between cortical and cardio-respiratory oscillations due to anæsthesia with propofol and sevoflurane. Philosophical Transactions of the Royal Society of London A, 374 (2067). ISSN 0264-3820

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Abstract

The precise mechanisms underlying general anæsthesia pose important and still open questions. To address them, we have studied anæsthesia induced by the widely-used (intravenous) propofol and (inhalational) sevoflurane anæsthetics, computing cross-frequency coupling functions between neuronal, cardiac, and respiratory oscillations in order to determine their mutual interactions. The phase domain coupling function reveals the form of the function defining the mechanism of an interaction, as well as its coupling strength. Using a method based on dynamical Bayesian inference, we have thus identified and analyzed the coupling functions for six relationships. By quantitative assessment of the forms and strengths of the couplings, we have revealed how these relationships are altered by anæsthesia, also showing that some of them are differently affected by propofol and sevoflurane. These findings, together with the novel coupling function analysis, offer a new direction in the assessment of general anæsthesia and neurophysiological interactions in general.

Item Type: Journal Article
Journal or Publication Title: Philosophical Transactions of the Royal Society of London A
Additional Information: c 2016 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/ by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Subjects:
Departments: Faculty of Science and Technology > Physics
ID Code: 78216
Deposited By: ep_importer_pure
Deposited On: 12 Feb 2016 10:58
Refereed?: Yes
Published?: Published
Last Modified: 17 Oct 2019 00:47
URI: https://eprints.lancs.ac.uk/id/eprint/78216

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