Supra-threshold auditory brainstem response amplitudes in humans:Test-retest reliability, electrode montage and noise exposure

Prendergast, Garreth and Tu, Wenhe and Guest, Hannah and Millman, Rebecca and Kluk, Karolina and Couth, Samuel and Munro, Kevin and Plack, Christopher John (2018) Supra-threshold auditory brainstem response amplitudes in humans:Test-retest reliability, electrode montage and noise exposure. Hearing Research, 364. pp. 38-47. ISSN 0378-5955

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Abstract

The auditory brainstem response (ABR) is a sub-cortical evoked potential in which a series of well-defined waves occur in the first 10 ms after the onset of an auditory stimulus. Wave V of the ABR, particularly wave V latency, has been shown to be remarkably stable over time in individual listeners. However, little attention has been paid to the reliability of wave I which reflects auditory nerve activity. This ABR component has attracted interest recently, as wave I amplitude has been identified as a possible non-invasive measure of noise-induced cochlear synaptopathy. The current study aimed to determine whether ABR wave I amplitude has sufficient test-retest reliability to detect impaired auditory nerve function in an otherwise normal-hearing listener. Thirty normal-hearing females were tested, divided into equal groups of low- and high-noise exposure. The stimulus was an 80 dB nHL click. ABR recordings were made from the ipsilateral mastoid and from the ear canal (using a tiptrode). Although there was some variability between listeners, wave I amplitude had high test-retest reliability, with an intraclass correlation coefficient (ICC) comparable to that for wave V amplitude. There were slight gains in reliability for wave I amplitude when recording from the ear canal (ICC of 0.88) compared to the mastoid (ICC of 0.85). The summating potential (SP) and ratio of SP to wave I were also quantified and found to be much less reliable than measures of wave I and V amplitude. Finally, we found no significant differences in the amplitude of any wave components between low- and high-noise exposure groups. We conclude that, if the other sources of between-subject variability can be controlled, wave I amplitude is sufficiently reliable to accurately characterize individual differences in auditory nerve function.

Item Type:
Journal Article
Journal or Publication Title:
Hearing Research
Additional Information:
This is the author’s version of a work that was accepted for publication in Hearing Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Hearing Research, 364, 2018 DOI: 10.1016/j.heares.2018.04.002
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2800/2809
Subjects:
ID Code:
124399
Deposited By:
Deposited On:
05 Apr 2018 13:28
Refereed?:
Yes
Published?:
Published
Last Modified:
22 Sep 2020 03:48