Items where Author is "Middleton, David A"

Journal Article

Townsend, David and Hughes, Eleri and Akien, Geoffrey and Stewart, Katie L. and Radford, Sheena E and Rochester, David and Middleton, David A (2018) Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin. Journal of Biological Chemistry, 293 (33). pp. 12877-12893. ISSN 0021-9258

Middleton, David A and Madine, Jillian and Castelletto, Valeria and Hamley, Ian W (2013) Insights into the Molecular Architecture of a Peptide Nanotube Using FTIR and Solid-State NMR Spectroscopic Measurements on an Aligned Sample. Angewandte Chemie International Edition, 52 (40). pp. 10537-10540. ISSN 1433-7851

Patching, Simon G and Henderson, Peter J F and Sharples, David J and Middleton, David A (2013) Probing the contacts of a low-affinity substrate with a membrane-embedded transport protein using 1H-13C cross-polarisation magic-angle spinning solid-state NMR. Molecular Membrane Biology, 30 (2). pp. 129-37. ISSN 1464-5203

Madine, Jillian and Pandya, Maya J and Hicks, Matthew R and Rodger, Alison and Yates, Edwin A and Radford, Sheena E and Middleton, David A (2012) Site-specific identification of an aβ fibril-heparin interaction site by using solid-state NMR spectroscopy. Angewandte Chemie International Edition, 51 (52). pp. 13140-3. ISSN 1433-7851

Madine, Jillian and Davies, Hannah A and Shaw, Christopher and Hamley, Ian W and Middleton, David A (2012) Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks. Chemical Communications, 48 (24). pp. 2976-8. ISSN 1359-7345

Shaw, Christopher P and Middleton, David A and Volk, Martin and Lévy, Raphaël (2012) Amyloid-derived peptide forms self-assembled monolayers on gold nanoparticle with a curvature-dependent β-sheet structure. ACS Nano, 6 (2). pp. 1416-26. ISSN 1936-0851

Davies, Hannah A and Madine, Jillian and Middleton, David A (2012) Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin. June 2002. ISSN 1460-4582, 18 (1). pp. 65-72. ISSN 0893-3200

Middleton, David A and Hughes, Eleri and Esmann, Mikael (2011) The conformation of ATP within the Na,K-ATPase nucleotide site : a statistically constrained analysis of REDOR solid-state NMR data. Angewandte Chemie International Edition, 50 (31). pp. 7041-4. ISSN 1433-7851

Hughes, Eleri and Whittaker, Christopher A P and Barsukov, Igor L and Esmann, Mikael and Middleton, David A (2011) A study of the membrane association and regulatory effect of the phospholemman cytoplasmic domain. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1808 (4). pp. 1021-31. ISSN 0005-2736

Middleton, David A (2011) Solid-state NMR detection of 14N-13C dipolar couplings between amino acid side groups provides constraints on amyloid fibril architecture. June 2002. ISSN 1460-4582, 49 (2). pp. 65-9. ISSN 0893-3200

Edwards, Rachel and Madine, Jillian and Fielding, Lee and Middleton, David A (2010) Measurement of multiple torsional angles from one-dimensional solid-state NMR spectra : application to the conformational analysis of a ligand in its biological receptor site. June 2002. ISSN 1460-4582, 12 (42). pp. 13999-4008. ISSN 0893-3200

Hughes, Eleri and Edwards, Rachel and Middleton, David A (2010) Heparin-derived oligosaccharides interact with the phospholamban cytoplasmic domain and stimulate SERCA function. Biochemical and Biophysical Research Communications, 401 (3). pp. 370-5. ISSN 0006-291X

Madine, Jillian and Middleton, David A (2010) Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medin. June 2002. ISSN 1460-4582, 39 (9). pp. 1281-8. ISSN 0893-3200

Madine, Jillian and Wang, Xiaoyan and Brown, David R and Middleton, David A (2009) Evaluation of beta-alanine- and GABA-substituted peptides as inhibitors of disease-linked protein aggregation. June 2002. ISSN 1460-4582, 10 (12). pp. 1982-7. ISSN 0893-3200

Amijee, Hozefa and Madine, Jill and Middleton, David A and Doig, Andrew J (2009) Inhibitors of protein aggregation and toxicity. Biochemical Society Transactions, 37 (Pt 4). pp. 692-6. ISSN 0300-5127

Patching, Simon G and Edwards, Rachel and Middleton, David A (2009) Structural analysis of uniformly (13)C-labelled solids from selective angle measurements at rotational resonance. June 2002. ISSN 1460-4582, 199 (2). pp. 242-6. ISSN 0893-3200

Middleton, David A and Hughes, Eleri and Fedosova, Natalya U and Esmann, Mikael (2009) Solid-state NMR studies of adenosine 5'-triphosphate freeze-trapped in the nucleotide site of Na,K-ATPase. June 2002. ISSN 1460-4582, 10 (11). pp. 1789-92. ISSN 0893-3200

Madine, Jillian and Clayton, Jonathan C and Yates, Edwin A and Middleton, David A (2009) Exploiting a (13)C-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils. Organic and Biomolecular Chemistry, 7 (11). pp. 2414-20. ISSN 1477-0520

Madine, Jillian and Copland, Alastair and Serpell, Louise C and Middleton, David A (2009) Cross-beta spine architecture of fibrils formed by the amyloidogenic segment NFGSVQFV of medin from solid-state NMR and X-ray fiber diffraction measurements. Biochemistry, 48 (14). pp. 3089-99. ISSN 0006-2960

Hughes, Eleri and Clayton, Jonathan C and Middleton, David A (2009) Cytoplasmic residues of phospholamban interact with membrane surfaces in the presence of SERCA : a new role for phospholipids in the regulation of cardiac calcium cycling? Biochimica et Biophysica Acta (BBA) - Biomembranes, 1788 (2). pp. 559-66. ISSN 0005-2736

Madine, Jillian and Jack, Edward and Stockley, Peter G and Radford, Sheena E and Serpell, Louise C and Middleton, David A (2008) Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fiber diffraction. Journal of the American Chemical Society, 130 (45). pp. 14990-5001. ISSN 0002-7863

Patching, Simon G and Psakis, Georgios and Baldwin, Stephen A and Baldwin, Jocelyn and Henderson, Peter J F and Middleton, David A (2008) Relative substrate affinities of wild-type and mutant forms of the Escherichia coli sugar transporter GalP determined by solid-state NMR. Molecular Membrane Biology, 25 (6-7). pp. 474-84. ISSN 1464-5203

Madine, Jillian and Hughes, Eleri and Doig, Andrew J and Middleton, David A (2008) The effects of alpha-synuclein on phospholipid vesicle integrity : a study using 31P NMR and electron microscopy. Molecular Membrane Biology, 25 (6-7). pp. 518-27. ISSN 1464-5203

Madine, Jillian and Doig, Andrew J and Middleton, David A (2008) Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR. Journal of the American Chemical Society, 130 (25). pp. 7873-81. ISSN 0002-7863

Patching, Simon G and Henderson, Peter J F and Herbert, Richard B and Middleton, David A (2008) Solid-state NMR spectroscopy detects interactions between tryptophan residues of the E. coli sugar transporter GalP and the alpha-anomer of the D-glucose substrate. Journal of the American Chemical Society, 130 (4). pp. 1236-44. ISSN 0002-7863

Boland, Martin P and Middleton, David A (2008) The dynamics and orientation of a lipophilic drug within model membranes determined by 13C solid-state NMR. Physical Chemistry Chemical Physics, 10 (1). pp. 178-85. ISSN 1463-9076

Jack, Edward R and Madine, Jillian and Lian, Lu-Yun and Middleton, David A (2008) Membrane interactions of peptides representing the polybasic regions of three Rho GTPases are sensitive to the distribution of arginine and lysine residues. Molecular Membrane Biology, 25 (1). pp. 14-22. ISSN 0968-7688