Items where Author is "Jaki, Thomas"

Daniells, Libby and Mozgunov, Pavel and Barnett, Helen and Bedding, Alun and Jaki, Thomas (2025) How to Add Baskets to an Ongoing Basket Trial with Information Borrowing. Statistical Methods in Medical Research. ISSN 0962-2802

Barnett, Helen and Boix, Oliver and Kontos, Dimitris and Jaki, Thomas (2025) Joint TITE-CRM : A Design for Dose Finding Studies for Therapies with Late-Onset Safety and Activity Outcomes. Statistics in Biopharmaceutical Research, 17 (1). pp. 149-160. ISSN 1946-6315

Daniells, Libby and Mozgunov, Pavel and Jaki, Thomas and Barnett, Helen and Bedding, Alun (2025) Design and Analysis of Basket Clinical Trials. PhD thesis, Lancaster University.

Jaki, Thomas and Barnett, Helen and Titman, Andrew and Mozgunov, Pavel (2024) A Seamless Phase I/II Platform Design with a Time-To-Event Efficacy Endpoint for Potential COVID-19 Therapies. Statistical Methods in Medical Research, 33 (11-12). pp. 2115-2130. ISSN 0962-2802

Greenstreet, Peter and Jaki, Thomas and Bedding, Alun and Harbron, Chris and Mozgunov, Pavel (2024) A multi‐arm multistage platform design that allows preplanned addition of arms while still controlling the family‐wise error. Statistics in Medicine, 43 (19). pp. 3613-3632. ISSN 0277-6715

Greenstreet, Peter and Jaki, Thomas and Mozgunov, Pavel (2024) Design and analysis of platform trials. PhD thesis, Lancaster University.

Barnett, Helen and George, Matthew and Skanji, Donia and Saint-Hilary, Gaelle and Jaki, Thomas and Mozgunov, Pavel (2024) A Comparison of Model-Free Phase I Dose Escalation Designs for Dual-Agent Combination Therapies. Statistical Methods in Medical Research, 33 (2). pp. 203-226. ISSN 0962-2802

Law, Martin and Couturier, Dominique Laurent and Choodari-Oskooei, Babak and Crout, Phillip and Gamble, Carrol and Jacko, Peter and Pallmann, Philip and Pilling, Mark and Robertson, David S. and Robling, Michael and Sydes, Matthew R. and Villar, Sofía S. and Wason, James and Wheeler, Graham and Williamson, S. Faye and Yap, Christina and Jaki, Thomas (2023) Correction : Medicines and Healthcare products Regulatory Agency’s “Consultation on proposals for legislative changes for clinical trials”: a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing (BMC Trials, (2023), 24, 1, (640), 10.1186/s13063-023-07576-7). Trials, 24 (1): 744. ISSN 1745-6215

Law, Martin and Couturier, Dominique-Laurent and Choodari-Oskooei, Babak and Crout, Phillip and Gamble, Carrol and Jacko, Peter and Pallmann, Philip and Pilling, Mark and Robertson, David S. and Robling, Michael and Sydes, Matthew R. and Villar, Sofía S. and Wason, James and Wheeler, Graham and Williamson, S. Faye and Yap, Christina and Jaki, Thomas (2023) Medicines and Healthcare products Regulatory Agency’s “Consultation on proposals for legislative changes for clinical trials”: a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing. Trials, 24 (1): 640. ISSN 1745-6215

Daniells, Libby and Mozgunov, Pavel and Bedding, Alun and Jaki, Thomas (2023) A comparison of Bayesian information borrowing methods in basket trials and a novel proposal of modified exchangeability‐nonexchangeability method. Statistics in Medicine. ISSN 0277-6715

Serra, Alessandra and Mozgunov, Pavel and Jaki, Thomas (2023) A Bayesian multi‐arm multi‐stage clinical trial design incorporating information about treatment ordering. Statistics in Medicine, 42 (16). pp. 2841-2854. ISSN 0277-6715

Solovyeva, Olga and Dimairo, Munyaradzi and Weir, Christopher J. and Hee, Siew Wan and Espinasse, Aude and Ursino, Moreno and Patel, Dhrusti and Kightley, Andrew and Hughes, Sarah and Jaki, Thomas and Mander, Adrian and Evans, Thomas R. Jeffry and Lee, Shing and Hopewell, Sally and Rantell, Khadija Rerhou and Chan, An-Wen and Bedding, Alun and Stephens, Richard and Richards, Dawn and Roberts, Lesley and Kirkpatrick, John and de Bono, Johann and Yap, Christina (2023) Development of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials : the DEFINE study. BMC Medicine, 21 (1): 246. ISSN 1741-7015

Jackson, Holly and Jaki, Thomas (2023) An alternative to traditional sample size determination for small patient populations. Statistics in Biopharmaceutical Research, 15 (3). pp. 596-607. ISSN 1946-6315

Barnett, Helen and Boix, Oliver and Kontos, Dimitris and Jaki, Thomas (2023) Backfilling cohorts in phase I dose-escalation studies. Clinical Trials, 20 (3). pp. 261-268. ISSN 1740-7745

Zheng, Haiyan and Jaki, Thomas and Wason, James M.S. (2023) Bayesian sample size determination using commensurate priors to leverage pre‐experimental data. Biometrics, 79 (2). pp. 669-683. ISSN 0006-341X

Graham, Emily and Harbron, Chris and Jaki, Thomas (2023) Updating the probability of study success for combination therapies using related combination study data. Statistical Methods in Medical Research, 32 (4). pp. 712-731. ISSN 0962-2802

Barnett, Helen Yvette and Villar, Sofía S. and Geys, Helena and Jaki, Thomas (2023) A novel statistical test for treatment differences in clinical trials using a response‐adaptive forward‐looking Gittins Index Rule. Biometrics, 79 (1). pp. 86-97. ISSN 0006-341X

Robertson, David S. and Choodari‐Oskooei, Babak and Dimairo, Munya and Flight, Laura and Pallmann, Philip and Jaki, Thomas (2023) Point estimation for adaptive trial designs I : A methodological review. Statistics in Medicine, 42 (2). pp. 122-145. ISSN 0277-6715

Jackson, Holly and Titman, Andrew and Jaki, Thomas (2023) Rare Disease Trials : Beyond the Randomised Controlled Trial. PhD thesis, Lancaster University.

Barnett, Helen and Boix, Oliver and Kontos, Dimitris and Jaki, Thomas (2022) Dose finding studies for therapies with late‐onset toxicities : A comparison study of designs. Statistics in Medicine, 41 (30). pp. 5767-5788. ISSN 0277-6715

Mozgunov, Pavel and Jaki, Thomas and Gounaris, Ioannis and Goddemeier, Thomas and Victor, Anja and Grinberg, Marianna (2022) Practical implementation of the partial ordering continual reassessment method in a Phase I combination‐schedule dose‐finding trial. Stat. Med., 41 (30). pp. 5789-5809. ISSN 0277-6715

Wason, James M. S. and Dimairo, Munyaradzi and Biggs, Katie and Bowden, Sarah and Brown, Julia and Flight, Laura and Hall, Jamie and Jaki, Thomas and Lowe, Rachel and Pallmann, Philip and Pilling, Mark A. and Snowdon, Claire and Sydes, Matthew R. and Villar, Sofía S. and Weir, Christopher J. and Wilson, Nina and Yap, Christina and Hancock, Helen and Maier, Rebecca (2022) Practical guidance for planning resources required to support publicly-funded adaptive clinical trials. BMC Medicine, 20 (1): 254. ISSN 1741-7015

Mozgunov, Pavel and Paoletti, Xavier and Jaki, Thomas (2022) A Benchmark for Dose Finding Studies with Unknown Ordering. Biostatistics, 23 (3). pp. 721-737. ISSN 1465-4644

Serra, Alessandra and Mozgunov, Pavel and Jaki, Thomas and Rigat, Fabio (2022) What is the expected benefit of patient-centric clinical development in oncology? Journal of Biopharmaceutical Statistics, 32 (3). pp. 414-426. ISSN 1054-3406

Khoo, Saye H and Fitzgerald, Richard and Fletcher, Thomas and Ewings, Sean and Jaki, Thomas and Lyon, Rebecca and Downs, Nichola and Walker, Lauren and Tansley-Hancock, Olana and Greenhalf, William and Woods, Christie and Reynolds, Helen and Marwood, Ellice and Mozgunov, Pavel and Adams, Emily and Bullock, Katie and Holman, Wayne and Bula, Marcin D and Gibney, Jennifer L and Saunders, Geoffrey and Corkhill, Andrea and Hale, Colin and Thorne, Kerensa and Chiong, Justin and Condie, Susannah and Pertinez, Henry and Painter, Wendy and Wrixon, Emma and Johnson, Lucy and Yeats, Sara and Mallard, Kim and Radford, Mike and Fines, Keira and Shaw, Victoria and Owen, Andrew and Lalloo, David G and Jacobs, Michael and Griffiths, Gareth (2021) Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2 : a Phase I, open-label, dose-escalating, randomized controlled study. Journal of Antimicrobial Chemotherapy, 76 (12). pp. 3286-3295. ISSN 0305-7453

Wilson, Nina and Biggs, Katie and Bowden, Sarah and Brown, Julia and Dimairo, Munyaradzi and Flight, Laura and Hall, Jamie and Hockaday, Anna and Jaki, Thomas and Lowe, Rachel and Murphy, Caroline and Pallmann, Philip and Pilling, Mark A and Snowdon, Claire and Sydes, Matthew R and Villar, Sofía S and Weir, Christopher J and Welburn, Jessica and Yap, Christina and Maier, Rebecca and Hancock, Helen and Wason, James M S (2021) Costs and staffing resource requirements for adaptive clinical trials : quantitative and qualitative results from the Costing Adaptive Trials project. BMC Medicine, 19 (1): 251. ISSN 1741-7015

Ramdharry, Gita and Buscemi, Valentina and Boaz, Annette and Dawes, Helen and Jaki, Thomas and Jones, Fiona and Marsden, Jonathan and Paul, Lorna and Playle, Rebecca and Randell, Elizabeth and Robling, Michael and Rochester, Lynn and Busse, Monica (2021) Proposing a Core Outcome Set for Physical Activity and Exercise Interventions in People With Rare Neurological Conditions. Frontiers in Rehabilitation Sciences, 2: 705474. ISSN 2673-6861

Desai, Yasin and Jaki, Thomas and Beresford, Michael W and Burnett, Thomas and Eleftheriou, Despina and Jacobe, Heidi and Leone, Valentina and Li, Suzanne and Mozgunov, Pavel and Ramanan, Athimalaipet V and Torok, Kathryn S and Anderson, Marina E and Anton, Jordi and Avcin, Tadej and Felton, Jessie and Foeldvari, Ivan and Laguda, Bisola and McErlane, Flora and Shaw, Lindsay and Zulian, Francesco and Pain, Clare E (2021) Prior elicitation of the efficacy and tolerability of Methotrexate and Mycophenolate Mofetil in Juvenile Localised Scleroderma. AMRC Open Research, 3. p. 20. ISSN 2517-6900

Kuhlemeier, Alena and Desai, Yasin and Tonigan, Alexandra and Witkiewitz, Katie and Jaki, Thomas and Hsiao, Yu-Yu and Chang, Chi and Van Horn, M. Lee (2021) Applying methods for personalized medicine to the treatment of alcohol use disorder. Journal of Consulting and Clinical Psychology, 89 (4). pp. 288-300. ISSN 0022-006X

Titman, Andrew and Wolfsegger, Martin J. and Jaki, Thomas (2021) Recurrent events modelling of haemophilia bleeding events. Journal of the Royal Statistical Society: Series C (Applied Statistics), 70 (2). pp. 351-371. ISSN 0035-9254

Mozgunov, Pavel and Knight, Rochelle and Barnett, Helen and Jaki, Thomas (2021) Using an Interaction Parameter in Model-Based Phase I Trials for Combination Treatments? : A Simulation Study. International Journal of Environmental Research and Public Health, 18 (1): 345. ISSN 1660-4601

Mozgunov, Pavel and Jaki, Thomas and Paoletti, Xavier (2020) Using a Dose-Finding Benchmark to Quantify the Loss Incurred by Dichotomisation in Phase II Dose-Ranging Studies. Biometrical Journal, 62 (7). pp. 1717-1729. ISSN 0323-3847

Mozgunov, Pavel and Gasparini, Mauro and Jaki, Thomas (2020) A surface-free design for phase I dual-agent combination trials. Statistical Methods in Medical Research, 29 (10). pp. 3093-3109. ISSN 0962-2802

Ballarini, N.M. and Chiu, Yi-Da and Koenig, Franz and Posch, Martin and Jaki, Thomas (2020) A Critical Review of Graphics for Subgroup Analyses in Clinical Trials. Pharmaceutical Statistics, 19 (5). pp. 541-560. ISSN 1539-1604

Whitehead, John and Desai, Yasin and Jaki, Thomas (2020) Estimation of treatment effects following a sequential trial of multiple treatments. Statistics in Medicine, 39 (11). pp. 1593-1609. ISSN 0277-6715

Williamson, S. Faye and Jaki, Thomas and Jacko, Peter (2020) Bayesian bandit models for the design of clinical trials. PhD thesis, Lancaster University.

Graham, Emily and Jaki, Thomas and Harbron, Chris (2020) Late stage combination drug development for improved portfolio-level decision-making. PhD thesis, Lancaster University.

Wan, Fang and Titman, Andrew and Jaki, Thomas (2019) Subgroup analysis of treatment effects for misclassified biomarkers with time-to-event data. Journal of the Royal Statistical Society: Series C (Applied Statistics), 68 (5). pp. 1447-1463. ISSN 0035-9254

Mozgunov, Pavel and Jaki, Thomas (2019) A flexible design for advanced Phase I/II clinical trials with continuous efficacy endpoints. Biometrical Journal, 61 (6). pp. 1477-1492. ISSN 0323-3847

Jaki, Thomas and Gordon, Allan and Forster, Pamela and Bijnens, Luc and Bornkamp, Bjoern and Brannath, Werner and Fontana, Roberto and Gasparini, Mauro and Hampson, Lisa V. and Jacobs, Tom and Jones, Byron and Paoletti, Xavier and Posch, Martin and Titman, Andrew and Vonk, Richardus and Koenig, Franz (2019) Response to comments on Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development. Pharm Stat 17(5):593-606, Sep/Oct 2018., DOI https://doi.org/10.1002/pst.1873. Pharmaceutical Statistics, 18 (3). pp. 284-286. ISSN 1539-1604

Cui, Xinping and Hsu, Jason C. and Jaki, Thomas (2019) Editorial for the MCP 2017 Special Issue. Biometrical Journal, 61 (1). p. 7. ISSN 0323-3847

Zheng, Haiyan and Hampson, Lisa and Jaki, Thomas (2019) Bayesian adaptive methods to incorporate preclinical data into phase I clinical trials. PhD thesis, Lancaster University.

Jaki, Thomas and Wason, James M. S. (2018) Multi-arm multi-stage trials can improve the efficiency of finding effective treatments for stroke : a case study. BMC Cardiovascular Disorders, 18 (1): 215. ISSN 1471-2261

Ballarini, N.M. and Rosenkranz, G.K. and Jaki, Thomas and König, F. and Posch, M. (2018) Subgroup identification in clinical trials via the predicted individual treatment effect. PLoS ONE, 13 (10): e0205971. ISSN 1932-6203

Vradi, Eleni and Brannath, Werner and Jaki, Thomas and Vonk, Richardus (2018) Model selection based on combined penalties for biomarker identification. Journal of Biopharmaceutical Statistics, 28 (4). pp. 735-749. ISSN 1054-3406

Mozgunov, Pavel and Jaki, Thomas (2018) Adaptive designs for complex dose finding studies. PhD thesis, Lancaster University.

Wadsworth, Ian and Jaki, Thomas and Hampson, Lisa (2018) Bridging the gap : using extrapolation to reduce the experimental burden in children. PhD thesis, Lancaster University.

Barnett, Helen Yvette and Geys, Helena and Jacobs, Tom and Jaki, Thomas (2017) Comparing sampling methods for pharmacokinetic studies using model averaged derived parameters. Statistics in Medicine, 36 (27). pp. 4301-4315. ISSN 0277-6715

Barnett, Helen Yvette and Jaki, Thomas (2017) Optimizing pharmacokinetic studies utilizing microsampling. PhD thesis, Lancaster University.

Kim, Minjung and Lamont, Andrea E. and Jaki, Thomas and Feaster, Daniel and Howe, George and Van Horn, M. Lee (2016) Impact of an equality constraint on the class-specific residual variances in regression mixtures : a Monte Carlo simulation study. Behavior Research Methods, 48 (2). pp. 813-826. ISSN 1554-351X

Wason, James and Jaki, Thomas (2016) A review of statistical designs for improving the efficiency of phase II studies in oncology. Statistical Methods in Medical Research, 25 (3). pp. 1010-1021. ISSN 0962-2802

Wason, James and Magirr, Dominic and Law, Martin and Jaki, Thomas (2016) Some recommendations for multi-arm multi-stage trials. Statistical Methods in Medical Research, 25 (2). pp. 716-727. ISSN 1477-0334

Jaki, Thomas and Hampson, Lisa (2016) Designing multi-arm multi-stage clinical trials using a risk-benefit criterion for treatment selection. Statistics in Medicine, 35 (4). pp. 522-533. ISSN 0277-6715

Van Horn, M. Lee and Feng, Y. and Kim, Minjung and Lamont, Andrea E. and Feaster, Daniel and Jaki, Thomas (2016) Using multilevel regression mixture models to identify level-1 heterogeneity in level-2 effects. Structural Equation Modeling, 23 (2). pp. 259-269. ISSN 1070-5511

Pushpakom, Sudeep P. and Taylor, Claire and Kolamunnage-Dona, Ruwanthi and Spowart, Catherine and Vora, Jiten and Garcıa-Finana, Marta and Kemp, Graham J. and Whitehead, John and Jaki, Thomas and Khoo, Saye and Williamson, Paula and Pirmohamed, Munir (2015) Telmisartan and Insulin Resistance in HIV (TAILoR) : protocol for a dose-ranging phase II randomised open-labelled trial of Telmisartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on combination antiretroviral therapy. BMJ Open, 5 (10): e009566. ISSN 2044-6055

Van Horn, M. Lee and Jaki, Thomas and Maysn, Katherine and Howe, George and Feaster, Daniel and Lamont, Andrea E. and George, Melissa and Kim, Minjung (2015) Evaluating differential effects using regression interactions and regression mixture models. Educational and Psychological Measurement, 75 (4). pp. 677-714. ISSN 0013-1644

Cotterill, Amy and Lorand, D. and Wang, J. and Jaki, Thomas (2015) A practical design for a dual-agent dose-escalation trial that incorporates pharmacokinetic data. Statistics in Medicine, 34 (13). pp. 2138-2164. ISSN 0277-6715

Davis, G. R. and Phillips, P. P. and Jaki, Thomas (2015) Adaptive clinical trials in tuberculosis : applications, challenges and solutions. International Journal of Tuberculosis and Lung Disease, 19 (6). pp. 626-634. ISSN 1027-3719

Jaki, Thomas (2015) Multi-arm clinical trials with treatment selection : what can be gained and at what price? Clinical Investigation, 5 (4). pp. 393-399. ISSN 2041-6792

Schaarschmidt, Frank and Hofmann, M. and Jaki, Thomas and Gr�uen, B. and Hothorn, Ludwig A. (2015) Statistical approaches for the determination of cut points in anti-drug antibody bioassays. Journal of Immunological Methods, 418. pp. 84-100. ISSN 1872-7905

Cotterill, Amy and Jaki, Thomas (2015) Novel methods for early phase clinical trials. PhD thesis, Lancaster University.

Magirr, Dominic and Stallard, Nigel and Jaki, Thomas (2014) Flexible sequential designs for multi-arm clinical trials. Statistics in Medicine, 33 (19). pp. 3269-3279. ISSN 0277-6715

Jaki, Thomas and Lawo, John-Philip and Wolfsegger, Martin J. and Allacher, Peter and Horling, Frank (2014) A comparison of methods for classifying samples as truly specific with confirmatory immunoassays. Journal of Pharmaceutical and Biomedical Analysis, 88. pp. 27-35. ISSN 0731-7085

Jaki, Thomas (2014) Designing multi-arm multi-stage clinical studies. In: Developments in statistical evaluation of clinical trials :. Springer, Berlin, pp. 51-69. ISBN 9783642553448

Jaki, Thomas and Kitsche, Andreas and Hothorn, Ludwig A (2014) Statistical evaluation of toxicological assays with zero or near-to-zero proportions or counts in the concurrent negative control group : a tutorial. JP Journal of Biostatistics, 11 (1). pp. 1-32. ISSN 0973-5143

Wolfsegger, Martin J. and Gutjahr, Georg and Engl, Werner and Jaki, Thomas (2014) A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships. Biometrics, 70 (1). pp. 103-109. ISSN 0006-341X

Jaki, Thomas and Pallmann, Philip and Wolfsegger, Martin J (2013) Authors' reply to comments on "Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data settings". Statistics in Medicine, 32 (30). pp. 5487-5488. ISSN 0277-6715

Jaki, Thomas and Pallmann, Philip and Wolfsegger, Martin J. (2013) Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designs. Statistics in Medicine, 32 (30). pp. 5469-5483. ISSN 0277-6715

Jaki, Thomas and Hothorn, Ludwig A. (2013) Statistical evaluation of toxicological assays : Dunnett or Williams test? − take both. Archives of Toxicology, 87 (11). pp. 1901-1910. ISSN 0340-5761

Wason, James and Jaki, Thomas and Stallard, Nigel (2013) Planning multi-arm screening studies within the context of a drug development programme. Statistics in Medicine, 32 (20). pp. 3424-3435. ISSN 0277-6715

Fagan, Abigail A. and Van Horn, M. Lee and Hawkins, J. David and Jaki, Thomas (2013) Differential effects of parental controls on adolescent substance use : for whom is the family most important? Journal of Quantitative Criminology, 29 (3). pp. 347-368. ISSN 0748-4518

Phillips, Alan and Fletcher, Chrissie and Atkinson, Gary and Channon, Eddie and Douiri, Abdel and Jaki, Thomas and Maca, Jeff and Morgan, David and Roger, James Henry and Terrill, Paul (2013) Multiplicity : discussion points from the PSI multiplicity expert group. Pharmaceutical Statistics, 12 (5). pp. 255-259. ISSN 1539-1604

Jaki, Thomas and Parry, Alice and Winter, Katherine and Hastings, Ian (2013) Analysing malaria drug trials on a per individual or a per clone basis : a comparison of methods. Statistics in Medicine, 32 (17). pp. 3020-3038. ISSN 0277-6715

Jaki, Thomas and Andre, Valerie and Su, Ting-Li and Whitehead, John (2013) Designing exploratory cancer trials using change in tumour size as primary endpoint. Statistics in Medicine, 32 (15). pp. 2544-2554. ISSN 0277-6715

Jaki, Thomas and Clive, Sally and Weir, Christopher (2013) Principles of dose finding studies in cancer : a comparison of trial designs. Cancer Chemotherapy and Pharmacology, 71 (5). pp. 1107-1114. ISSN 0344-5704

Jaki, Thomas (2013) Uptake of novel statistical methods for early phase clinical studies in the UK public sector. Clinical Trials, 10 (2). pp. 344-346. ISSN 1740-7745

Jaki, Thomas and Magirr, Dominic (2013) Considerations on covariates and endpoints in multi-arm multi-stage clinical trials selecting all promising treatments. Statistics in Medicine, 32 (7). pp. 1150-1163. ISSN 0277-6715

George, Melissa and Yang, Na and Jaki, Thomas and Feaster, Daniel and Lamont, Andrea E. and Van Horn, M. Lee and Wilson, Dawn K. (2013) Finite mixtures for simultaneously modelling differential effects and non-normal distributions. Multivariate Behavioral Research, 48 (6). pp. 816-844. ISSN 0027-3171

Magirr, Dominic and Jaki, Thomas and Posch, Martin and Klingelmueller, Florian (2013) Simultaneous confidence intervals that are compatible with closed testing in adaptive designs. Biometrika, 100 (4). pp. 985-996. ISSN 0006-3444

George, Melissa and Yang, Na and Van Horn, M. Lee and Smith, Jessalyn and Jaki, Thomas and Feaster, Daniel and Maysn, Katherine and Howe, George (2013) Using regression mixture models with non-normal data: examining an ordered polytomous approach. Journal of Statistical Computation and Simulation, 83 (4). pp. 757-770. ISSN 1563-5163

Wason, James and Jaki, Thomas (2012) Optimal design of multi-arm multi-stage trials. Statistics in Medicine, 31 (30). pp. 4269-4279. ISSN 1097-0258

Whitehead, John and Thygesen, Helene and Jaki, Thomas and Davis, S. and Halford, S. and Turner, H. and Cook, N. and Jodrell, Duncan (2012) A novel phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer. Statistics in Medicine, 31 (18). pp. 1931-1943. ISSN 1097-0258

Sperrin, Matthew and Jaki, Thomas (2012) Recovering Independent Associations in Genetics: A Comparison. Journal of Computational Biology, 19 (8). 978–987. ISSN 1066-5277

Magirr, Dominic and Jaki, Thomas and Whitehead, John (2012) A generalized Dunnett Test for Multi-arm Multi-stage Clinical Studies with Treatment Selection. Biometrika, 99 (2). pp. 494-501. ISSN 0006-3444

Jaki, Thomas and Wolfsegger, Martin J. (2012) Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs. Statistics in Medicine, 31 (11-12). pp. 1059-1073. ISSN 1097-0258

Van Horn, M. Lee and Smith, Jessalyn and Fagan, Abigail and Jaki, Thomas and Maysn, Katherine and Hawkins, D. and Feaster, Daniel and Howe, George (2012) Not quite normal: Consequences of violating the assumption of normality with regression mixture models. Structural Equation Modeling, 19 (2). pp. 227-249. ISSN 1070-5511

Jaki, Thomas and Lawo, John-Philip and Wolfsegger, Martin J. and Singer, Julia and Allacher, Peter and Horling, Frank (2011) A formal comparison of different methods for establishing cut points to distinguish positive and negative samples in immunoassays. Journal of Pharmaceutical and Biomedical Analysis, 55 (5). pp. 1148-1156. ISSN 0731-7085

Jaki, Thomas and Wolfsegger, Martin J. (2011) Estimation of pharmacokinetic parameters with the R package PK. Pharmaceutical Statistics, 10 (2). pp. 284-288. ISSN 1539-1604

Jaki, Thomas and West, R. Webster (2011) Symmetric maximum kernel likelihood estimation. Journal of Statistical Computation and Simulation, 81 (2). pp. 193-206. ISSN 1563-5163

Sperrin, Matthew and Jaki, Thomas (2010) Direct effects testing : a two-stage procedure to test for effect size and variable importance for correlated binary predictors and a binary response. Statistics in Medicine, 29 (24). pp. 2544-2556. ISSN 1097-0258

Jaki, Thomas and Wolfsegger, Martin J. and Lawo, John-Philip (2010) Establishing bioequivalence in complete and incomplete data designs using AUCs. Journal of Biopharmaceutical Statistics, 20 (4). pp. 803-820. ISSN 1054-3406

Baumgartner, Bernhard and Jaki, Thomas and Wolfsegger, Martin J. and Eder, B. and Schiviz, A. and Schwarz, H. P. and Muchitsch, E. M. (2010) Optimization, refinement and reduction of murine in vivo experiments to assess therapeutic approaches for hemophilia A. Laboratory Animals, 44 (3). pp. 211-217. ISSN 0023-6772

Sperrin, Matthew and Jaki, Thomas and Wit, Ernst (2010) Probabilistic relabelling strategies for the label switching problem in Bayesian mixture models. Statistics and Computing, 20 (3). pp. 357-366. ISSN 0960-3174

Jaki, Thomas (2010) Book review : Bioequivalence and statistics in clinical pharmacology. Journal of the Royal Statistical Society: Series A Statistics in Society, 173 (2). pp. 467-468. ISSN 0964-1998

Sperrin, Matthew and Jaki, Thomas (2010) Statistical methodology motivated by problems in genetics. PhD thesis, Lancaster University.

Wolfsegger, Martin J. and Jaki, Thomas (2009) Assessing systemic drug exposure in repeated dose toxicity studies in the case of complete and incomplete sampling. Biometrical Journal, 51 (6). pp. 1017-1026. ISSN 1521-4036

Jaki, Thomas (2009) Recording lectures as a service in a service course. Journal of Statistics Education, 17 (3). ISSN 1069-1898

Wolfsegger, Martin J. and Jaki, Thomas (2009) Non-compartmental estimation of pharmacokinetic parameters in serial sampling designs. Journal of Pharmacokinetics and Pharmacodynamics, 36 (5). pp. 479-494. ISSN 1573-8744

Wolfsegger, Martin J. and Jaki, Thomas and Dietrich, Barbara and Kunzler, Jackie A. and Barker, Kerry (2009) A note on statistical analysis of organ weights in non-clinical toxicological studies. Toxicology and Applied Pharmacology, 240 (1). pp. 117-122. ISSN 1096-0333

Van Horn, M. Lee and Jaki, Thomas and Maysn, Katherine and Ramey, Sharon Landesman and Smith, Jessalyn A. and Antaramian, Susan (2009) Assessing differential effects: Applying regression mixture models to identify variations in the influence of family resources on academic achievement. Developmental Psychology, 45 (5). pp. 1298-1313. ISSN 0012-1649

Jaki, Thomas and Autin, Melanie (2009) Using a problem-based approach to teach statistics to postgraduate science students : a case study. MSOR Connections, 9 (2). pp. 40-47. ISSN 1473-4869

Jaki, Thomas and Wolfsegger, Martin J. (2009) A theoretical framework for estimation of AUCs in complete and incomplete sampling designs. Statistics in Biopharmaceutical Research, 1 (2). pp. 176-184.

Whitehead, John and Jaki, Thomas (2009) One- and two-stage design proposals for a phase II trial comparing three active treatments with control using an ordered categorical endpoint. Statistics in Medicine, 28 (5). pp. 828-847. ISSN 1097-0258

Jaki, Thomas and Wolfsegger, Martin J. and Ploner, Meinhard (2009) Confidence Intervals for Ratios of AUC's in the Case of Serial Sampling : A Comparison of Seven Methods. Pharmaceutical Statistics, 8 (1). pp. 12-24. ISSN 1539-1604

Van Horn, M. Lee and Fagan, Abigail A. and Jaki, Thomas and Brown, Eric C. and Hawkins, J. David and Arthur, Michael W. and Abbott, Robert D. and Catalano, Richard F. (2008) Using Multilevel Mixtures to Evaluate Intervention Effects in Group Randomized Trials. Multivariate Behavioral Research, 43 (2). pp. 289-326. ISSN 0027-3171

Jaki, Thomas (2008) Book review: Applied Nonparametric Statistical Methods. Journal of Biopharmaceutical Statistics, 18 (2). pp. 393-395. ISSN 1054-3406

Jaki, Thomas and West, R. Webster (2008) Maximum kernel likelihood estimation. Journal of Computational and Graphical Statistics, 17 (4). pp. 976-993. ISSN 1061-8600

Wolfsegger, Martin J. and Jaki, Thomas (2006) Simultaneous confidence intervals by iteratively adjusted alpha for relative effects in the one-way layout. Statistics and Computing, 16 (1). pp. 15-23. ISSN 0960-3174

Wolfsegger, Martin J. and Jaki, Thomas (2005) Estimation of AUC from 0 to Infinity in Serial Sacrifice Designs. Journal of Pharmacokinetics and Pharmacodynamics, 32 (5-6). pp. 757-766. ISSN 1573-8744