Wolfsegger, Martin J. and Gutjahr, Georg and Engl, Werner and Jaki, Thomas (2014) A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships. Biometrics, 70 (1). pp. 103-109. ISSN 0006-341X
Full text not available from this repository.Abstract
This article proposes a new multiple-testing approach for estimation of the minimum effective dose allowing for non-monotonous dose–response shapes. The presented approach combines the advantages of two commonly used methods. It is shown that the new approach controls the error rate of underestimating the true minimum effective dose. Monte Carlo simulations indicate that the proposed method outperforms alternative methods in many cases and is only marginally worse in the remaining situations.