Consistency of estimators of the population-scaled recombination rate.

Fearnhead, Paul (2003) Consistency of estimators of the population-scaled recombination rate. Theoretical Population Biology, 64 (1). pp. 67-79. ISSN 1096-0325

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Abstract

We consider (approximate) likelihood methods for estimating the population-scaled recombination rate from population genetic data. We show that the dependence between the data from two regions of a chromosome decays inversely with the amount of recombination between the two regions. We use this result to show that the maximum likelihood estimator (mle) for the recombination rate, based on the composite likelihood of Fearnhead and Donnelly, is consistent. We also consider inference based on the pairwise likelihood of Hudson. We consider two approximations to this likelihood, and prove that the mle based on one of these approximations is consistent, while the mle based on the other approximation (which is used by McVean, Awadalla and Fearnhead) is not.

Item Type:
Journal Article
Journal or Publication Title:
Theoretical Population Biology
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1100/1105
Subjects:
?? asymptoticscomposite likelihoodmaximum likelihood estimatorspairwise likelihoodrecombination rateecology, evolution, behavior and systematicsqa mathematics ??
ID Code:
9816
Deposited By:
Users 810 not found.
Deposited On:
20 Jun 2008 09:08
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jul 2024 11:42