Protein aggregation, metals and oxidative stress in neurodegenerative diseases.

Tabner, Brian J. and El-Agnaf, Omar M. A. and German, M. J. and Fullwood, Nigel J. and Allsop, David (2005) Protein aggregation, metals and oxidative stress in neurodegenerative diseases. Biochemical Society Transactions, 33 (5). pp. 1082-1086. ISSN 0300-5127

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Abstract

There is clear evidence implicating oxidative stress in the pathology of many different neurodegenerative diseases. ROS (reactive oxygen species) are the primary mediators of oxidative stress and many of the aggregating proteins and peptides associated with neurodegenerative disease can generate hydrogen peroxide, a key ROS, apparently through interactions with redox-active metal ions. Our recent results suggest that ROS are generated during the very early stages of protein aggregation, when protofibrils or soluble oligomers are present, but in the absence of mature amyloid fibrils. The generation of ROS during early-stage protein aggregation may be a common, fundamental molecular mechanism underlying the pathogenesis of oxidative damage, neurodegeneration and cell death in several different neurodegenerative diseases. Drugs that specifically target this process could be useful in the future therapy of these diseases.

Item Type:
Journal Article
Journal or Publication Title:
Biochemical Society Transactions
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1303
Subjects:
?? amyloidhydrogen peroxidemetalneurodegenerationoligomeroxidative stress.humansneurotoxinsproteinsbiochemistryqh301 biology ??
ID Code:
8876
Deposited By:
Deposited On:
15 May 2008 13:06
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jul 2024 11:34