Relation between selectivity and conductivity in narrow ion channels

Luchinsky, D. G. and Gibby, W. A.T. and Kaufman, I. Kh and McClintock, P. V.E. and Timucin, D. A. (2017) Relation between selectivity and conductivity in narrow ion channels. In: 2017 International Conference on Noise and Fluctuations, ICNF 2017. Institute of Electrical and Electronics Engineers Inc., LTU. ISBN 9781509027613

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To establish the general statistical mechanical properties of highly conductive but selective nano-filters we develop an equilibrium statistical-mechanical theory of the KcsA filter, find the probabilities for the filter to bind ions from the mixed intra- and extra-cellular solutions, and evaluate the conductivity of the filter in its linear response regime. The results provide first principles analytical resolution of the long-standing paradox - how can narrow filter conduct potassium ions at nearly the rate of free diffusion while strongly selecting them over sodium ions - and are applicable to a wide range of biological and artificial channels.

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23 Oct 2017 11:04
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16 Sep 2023 03:12