Gene delivery with organic electronic biomaterials

Clancy, Kathryn and Hardy, John George (2017) Gene delivery with organic electronic biomaterials. Current Pharmaceutical Design, 23 (24). pp. 3614-3625. ISSN 1873-4286

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Abstract

Gene therapy may be capable of treating a variety of diseases, a prerequisite of which is the successful delivery of polynucleic acids (e.g., DNA, RNA) to a patient’s cells. Delivery can be achieved technologically (e.g., using electroporation), using viruses (natural gene delivery vectors) or non-viral vectors (e.g., lipids, nanoparticles, polymers). This article aims to give the reader an overview of the use of organic electronic materials (i.e., fullerenes, graphenes and conjugated polymers) as non-viral gene delivery vectors.