Sacrificial crystal templating of hyaluronic acid-based hydrogels

Thomas, Richelle and Chung, Paul and Modi, Shan P. and Hardy, John George and Schmidt, Christine E (2017) Sacrificial crystal templating of hyaluronic acid-based hydrogels. European Polymer Journal, 87. pp. 487-496. ISSN 0014-3057

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Natural tissues have intricate structures organized in a hierarchical fashion over multiple length scales (Å to cm). These tissues commonly incorporate pores as a key feature that may regulate cell behavior. To enable the development of tissues scaffolds with biomimetic pore structures, it is important to investigate methods to impart pores to biomaterials, such as the use of novel sacrificial porogens. Here we report the use of sacrificial crystals to impart pores to biopolymer hydrogels (based on a methacrylated hyaluronic acid derivative) with macroscopic crystal templated pores embedded within them. The pore structure was investigated using microscopy (cryoSEM and confocal), and the specific sacrificial porogen used was found not only to impact the pore structure, but also swelling and mechanical properties. Such templated hydrogels have prospects for application as instructive tissue scaffolds (where the pore structure controls cell alignment, migration, etc.).

Item Type:
Journal Article
Journal or Publication Title:
European Polymer Journal
Additional Information:
This is the author’s version of a work that was accepted for publication in European Polymer Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Polymer Journal, 87, 2017 DOI: 10.1016/j.europolymj.2016.10.022
Uncontrolled Keywords:
?? biomaterialsregenerative medicinetissue scaffoldhydrogelmacroporeschemistry (miscellaneous)chemical engineering (miscellaneous)biomaterialsorganic chemistrypolymers and plasticsphysics and astronomy(all)sdg 3 - good health and well-being ??
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Deposited On:
28 Oct 2016 10:30
Last Modified:
31 Dec 2023 00:45