Holmes, Nicholas and Akien, Geoffrey R. and Savage, Robert J. D. and Stanetty, Christian and Baxendale, Ian R. and Blacker, A. John and Taylor, Brian A. and Woodward, Robert L. and Meadows, Rebecca E. and Bourne, Richard A. (2016) Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors. Reaction Chemistry and Engineering, 2016 (1). pp. 96-100.
Full text not available from this repository.Abstract
An automated continuous reactor for the synthesis of organic compounds, which uses online mass spectrometry (MS) for reaction monitoring and product quantification, is presented. Quantitative and rapid MS monitoring was developed and calibrated using HPLC. The amidation of methyl nicotinate with aqueous MeNH2 was optimised using design of experiments and a self-optimisation algorithm approach to produce >93% yield.