Coulomb blockade oscillations in biological ion channels

Kaufman, Igor Khaimovich and Gibby, William and Luchinsky, Dmitry and McClintock, Peter Vaughan Elsmere and Eisenberg, Robert S. (2015) Coulomb blockade oscillations in biological ion channels. In: Noise and Fluctuations (ICNF), 2015 International Conference on :. IEEE. ISBN 9781467383356

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The conduction and selectivity of calcium/sodium ion channels are described in terms of ionic Coulomb blockade, a phenomenon based on charge discreteness, an electrostatic exclusion principle, and stochastic ion motion through the channel. This novel approach provides a unified explanation of numerous observed and modelled conductance and selectivity phenomena, including the anomalous mole fraction effect and discrete conduction bands. Ionic Coulomb blockade and resonant conduction are similar to electronic Coulomb blockade and resonant tunnelling in quantum dots. The model is equally applicable to other nanopores.

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24 Aug 2016 08:20
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31 Dec 2023 01:34