Cohen-Woods, Sarah and Gaysina, Daria and Craddock, Nick and Farmer, Anne and Gray, Joanna and Gunasinghe, Cerisse and Hoda, Farzana and Jones, Lisa and Knight, Jo and Korszun, Ania and Owen, Michael J. and Sterne, Abram and Craig, Ian W. and McGuffin, Peter (2009) Depression Case Control (DeCC) study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder. Human Molecular Genetics, 18 (8). pp. 1504-1509. ISSN 0964-6906
Full text not available from this repository.Abstract
It has been suggested that alteration in the muscarinic-cholinergic system is involved in modulation of mood. Three studies have reported linkage on chromosome 7 with major depressive disorder (MDD) in or close to a region containing the muscarinic receptor CHRM2 gene. A haplotype of SNPs located in CHRM2 (rs1824024-rs2061174-rs324650) has been significantly associated with MDD in a previous study. We report the first study investigating this gene in a large, adequately powered, clinical depression case-control sample (n = 1420 cases, 1624 controls). Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. It is possible our failure to replicate may be a consequence of differences in definition of the MDD phenotype and/or ethnic differences.