A three-dimensional point process model for the spatial distribution of disease occurrence in relation to an exposure source

Grell, Kathrine and Diggle, Peter J. and Frederiksen, Kirsten and Schüz, Joachim and Cardis, Elisabeth and Andersen, Per Kragh (2015) A three-dimensional point process model for the spatial distribution of disease occurrence in relation to an exposure source. Statistics in Medicine, 34 (23). pp. 3170-3180. ISSN 0277-6715

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Abstract

We study methods for how to include the spatial distribution of tumours when investigating the relation between brain tumours and the exposure from radio frequency electromagnetic fields caused by mobile phone use. Our suggested point process model is adapted from studies investigating spatial aggregation of a disease around a source of potential hazard in environmental epidemiology, where now the source is the preferred ear of each phone user. In this context, the spatial distribution is a distribution over a sample of patients rather than over multiple disease cases within one geographical area. We show how the distance relation between tumour and phone can be modelled nonparametrically and, with various parametric functions, how covariates can be included in the model and how to test for the effect of distance. To illustrate the models, we apply them to a subset of the data from the Interphone Study, a large multinational case-control study on the association between brain tumours and mobile phone use.

Item Type:
Journal Article
Journal or Publication Title:
Statistics in Medicine
Additional Information:
This is the peer reviewed version of the following article: Grell, K., Diggle, P. J., Frederiksen, K., Schüz, J., Cardis, E., and Andersen, P. K. (2015) A three-dimensional point process model for the spatial distribution of disease occurrence in relation to an exposure source. Statist. Med., 34: 3170–3180. doi: 10.1002/sim.6538 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/sim.6538/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2600/2613
Subjects:
ID Code:
78105
Deposited By:
Deposited On:
10 Jun 2016 08:02
Refereed?:
Yes
Published?:
Published
Last Modified:
05 Apr 2020 03:47