Effects of persistent atrial fibrillation-induced electrical remodeling on atrial electro-mechanics – insights from a 3D model of the human atria

Adeniran, Ismail and Maclver, David H. and Garratt, Clifford J. and Ye, Jianqiao and Hancox, Jules C. and Zhang, Henggui (2015) Effects of persistent atrial fibrillation-induced electrical remodeling on atrial electro-mechanics – insights from a 3D model of the human atria. PLoS ONE, 10 (11). ISSN 1932-6203

[img]
Preview
PDF (Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics)
Plos_One.pdf - Published Version
Available under License Creative Commons Attribution.

Download (7MB)

Abstract

A 3D electromechanical model of the human atria was developed to investigate the effects of AFER on atrial electro-mechanics. Simulations were carried out in 3 conditions for 4states: (i) the control condition, representing the normal tissue (state 1) and the tissue 2–3months after cardio version (state 2) when the atrial tissue recovers its electrophysiological properties after completion of reverse electrophysiological remodelling; (ii) AFER-SR condition for AF-remodelled tissue with normal sinus rhythm (SR) (state 3); and (iii) AFER-AF condition for AF-remodeled tissue with re-entrant excitation waves (state 4). Our results indicate that at the cellular level, AFER (states 3 & 4) abbreviated action potentials and reduced the Ca2+content in the sarcoplasmic reticulum, resulting in a reduced amplitude of the intracellular Ca2+transient leading to decreased cell active force and cell shortening as compared to the control condition (states 1 & 2). Consequently at the whole organ level, atrial contraction in AFER-SR condition (state 3) was dramatically reduced. In the AFER-AF condition (state 4) atrial contraction was almost abolished.

Item Type:
Journal Article
Journal or Publication Title:
PLoS ONE
Additional Information:
© 2015 Adeniran et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700
Subjects:
ID Code:
76947
Deposited By:
Deposited On:
01 Dec 2015 15:28
Refereed?:
Yes
Published?:
Published
Last Modified:
08 Aug 2020 04:39