Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's disease

Ji, Chenhui and Xue, Guo-Fang and Li, Guanglai and Li, Dongfang and Holscher, Christian (2016) Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's disease. Reviews in the Neurosciences, 27 (1). pp. 61-70. ISSN 0334-1763

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Abstract

Glucose-dependent insulinotropic polypeptide (GIP) is a member of the incretin hormones and growth factors. Neurons express the GIP receptor, and GIP and its agonists can pass through the blood brain barrier and show remarkable neuroprotective effects by protecting synapse function and numbers, promoting neuronal proliferation, reducing amyloid plaques in the cortex and reducing the chronic inflammation response of the nervous system. Long-acting analogues of GIP that are protease resistant had been developed as a treatment for type 2 diabetes. It has been found that such GIP analogues show good protective effects in animal models of Alzheimer's disease. Novel dual agonist peptides that activate the GIP receptor and another incretin receptor, glucagon-like peptide -1 (GLP-1), are under development that show superior effects in diabetic patients compared to single GLP-1 agonists. The dual agonists also show great promise in treating neurodegenerative disorders, and there are currently several clinical trials ongoing, testing GLP-1 mimetics in people with Alzheimer's or Parkinson's disease.

Item Type:
Journal Article
Journal or Publication Title:
Reviews in the Neurosciences
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2800
Subjects:
ID Code:
75658
Deposited By:
Deposited On:
12 Apr 2016 13:18
Refereed?:
Yes
Published?:
Published
Last Modified:
27 Oct 2020 05:07