The rise in computational systems biology approaches for understanding NF-κB signaling dynamics

Williams, Richard and Timmis, Jon and Qwarnstrom, Eva E. (2015) The rise in computational systems biology approaches for understanding NF-κB signaling dynamics. Science Signaling, 8 (385): fs13. ISSN 1945-0877

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Abstract

A study by Cheng et al. in this issue of Science Signaling highlights the distinct single-cell signaling characteristics conferred by pathways mediated by the adaptor proteins MyD88 and TRIF in the TLR4-dependent activation of the transcription factor nuclear factor κB (NF-κB).