On the Choice of Genetic Distance in Spatial-Genetic Studies.

Fearnhead, P (2007) On the Choice of Genetic Distance in Spatial-Genetic Studies. Genetics, 177. pp. 427-434. ISSN 1943-2631

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We look at how to choose genetic distance so as to maximise the power of detecting spatial structure. We answer this question through analysin g two population genetic models that allow for a spatially structured population in a continuous habitat. These models, like most that incorporate spatial s tructure, can be characterised by a separation of time scales: the history of the sample can be split into a scattering and collecting phase, and it is only during the scattering phase that the spatial locations of the sample affects the coalescence times. Our results suggest that the optimal choice of genetic distance is based upon splitting a DNA sequence into segments, and counting the number of segments at which two sequences differ. The size of these segments depends on the length of the scattering phase for the population genetic model.

Item Type: Journal Article
Journal or Publication Title: Genetics
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1300/1311
Departments: Faculty of Science and Technology > Mathematics and Statistics
ID Code: 744
Deposited By: Prof Paul Fearnhead
Deposited On: 08 Nov 2007
Refereed?: Yes
Published?: Published
Last Modified: 17 Feb 2020 01:31
URI: https://eprints.lancs.ac.uk/id/eprint/744

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