Evidence from Raman spectroscopy of a putative link between inherent bone matrix chemistry and degenerative joint disease

Kerns, Jemma G. and Gikas, Panagiotis D. and Buckley, Kevin and Shepperd, Adam and Birch, Helen L. and McCarthy, Ian and Miles, Jonathan and Briggs, Timothy W. R. and Keen, Richard and Parker, Anthony W. and Matousek, Pavel and Goodship, Allen E. (2014) Evidence from Raman spectroscopy of a putative link between inherent bone matrix chemistry and degenerative joint disease. Arthritis and Rheumatology, 66 (5). pp. 1237-1246. ISSN 2326-5191

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Abstract

Osteoarthritis (OA) is a common debilitating disease that results in degeneration of cartilage and bone in the synovial joints. Subtle changes in the molecular structure of the subchondral bone matrix occur and may be associated with cartilage changes. The aim of this study was to explore whether the abnormal molecular changes observed in the matrix of OA subchondral bone can be identified with Raman spectroscopy.

Item Type:
Journal Article
Journal or Publication Title:
Arthritis and Rheumatology
Additional Information:
© 2014 The Authors. Arthritis & Rheumatology is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2723
Subjects:
ID Code:
69435
Deposited By:
Deposited On:
14 May 2014 08:15
Refereed?:
Yes
Published?:
Published
Last Modified:
11 Jun 2020 03:17