Modelling the anesthetized brain with ensembles of neuronal and astrocytic oscillators

Hansard, Tom and Hale, Alison and Stefanovska, Aneta (2013) Modelling the anesthetized brain with ensembles of neuronal and astrocytic oscillators. In: AIP Proceedings :. American Institute of Physics.

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Abstract

We propose a minimalistic model of the anesthetized brain in order to study the generation of rhythms observed in electroencephalograms (EEGs) recorded from anesthetized humans. We propose that non-neuronal brain cells-astrocytes-play an important role in brain dynamics and that oscillation-based models may provide a simple way to study such dynamics. The model is capable of replicating the main features (i.e. slow and alpha oscillations) observed in EEGs. In addition, this model suggests that astrocytes are integral to the generation of slow EEG (∼0.7 Hz) rhythms. By including astrocytes in the model we take a first step towards investigating the interaction of the brain and cardiovasular system which are primarily connected via astrocytes. The model also illustrates that rich nonlinear dynamics can arise from basic oscillatory "building blocks" and therefore complex systems may be modelled in an uncomplicated way.

Item Type:
Contribution in Book/Report/Proceedings
ID Code:
67565
Deposited By:
Deposited On:
18 Nov 2013 09:42
Refereed?:
Yes
Published?:
Published
Last Modified:
16 Jul 2024 03:16