Taylor-Robinson, David and Whitehead, Margaret and Diderichsen, Finn and Olesen, Hanne Vebert and Pressler, Tania and Smyth, Rosalind L and Diggle, Peter (2012) Understanding the natural progression in %FEV1 decline in patients with cystic fibrosis : a longitudinal study. Thorax, 67 (10). pp. 860-866. ISSN 1468-3296
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Abstract
Forced expiratory volume in 1 s as a percentage of predicted (%FEV1) is a key outcome in cystic fibrosis (CF) and other lung diseases. As people with CF survive for longer periods, new methods are required to understand the way %FEV1 changes over time. An up to date approach for longitudinal modelling of %FEV1 is presented and applied to a unique CF dataset to demonstrate its utility at the clinical and population level.