Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions

Liotta, Lisa and Medina, Irene and Robinson, Jennifer and Carroll, Chris and Pan, Po-Shen and Corral, Ricardo and Johnston, Jennifer and Cook, Kristina and Curtis, Fiona and Sharples, Gary and McAlpine, Shelli (2004) Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions. Tetrahedron Letters, 45 (46). pp. 8447-8450. ISSN 0040-4039

Full text not available from this repository.

Abstract

Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics.

Item Type:
Journal Article
Journal or Publication Title:
Tetrahedron Letters
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3000/3002
Subjects:
ID Code:
51951
Deposited By:
Deposited On:
09 Dec 2011 11:46
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jan 2020 07:45