Liotta, Lisa and Medina, Irene and Robinson, Jennifer and Carroll, Chris and Pan, Po-Shen and Corral, Ricardo and Johnston, Jennifer and Cook, Kristina and Curtis, Fiona and Sharples, Gary and McAlpine, Shelli (2004) Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions. Tetrahedron Letters, 45 (46). pp. 8447-8450. ISSN 0040-4039
Full text not available from this repository.Abstract
Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics.