Immunogold labeling of cerebrovascular and neuritic plaque amyloid fibrils in Alzheimer's disease with an anti-β protein monoclonal antibody

Ikeda, S and Wong, C W and Allsop, D and Landon, M and Kidd, M and Glenner, G G (1987) Immunogold labeling of cerebrovascular and neuritic plaque amyloid fibrils in Alzheimer's disease with an anti-β protein monoclonal antibody. Laboratory Investigation, 57 (4). pp. 446-9. ISSN 0023-6837

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Abstract

A monoclonal antibody raised to a synthetic peptide consisting of residues 8 to 17 of the amyloid beta protein of Alzheimer's disease was employed for immunogold electron microscopic studies on amyloid fibrils of cerebrovascular walls and neuritic plaques in this disease. Electron microscopy revealed a specific gold labeling of the amyloid fibrils in these structures. This provides ultrastructural evidence that beta protein is intimately associated with the amyloid fibril. With previous chemical evidence, this observation supports the concentration that it is an intrinsic component of the fibril.

Item Type:
Journal Article
Journal or Publication Title:
Laboratory Investigation
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2734
Subjects:
?? ALZHEIMER DISEASEAMYLOIDAMYLOID BETA-PEPTIDESANTIBODIES, MONOCLONALHUMANSIMMUNOENZYME TECHNIQUESIMMUNOHISTOCHEMISTRYMICROSCOPY, ELECTRONNEUROFIBRILSCELL BIOLOGYMOLECULAR BIOLOGYPATHOLOGY AND FORENSIC MEDICINE ??
ID Code:
50871
Deposited By:
Deposited On:
01 Nov 2011 16:15
Refereed?:
Yes
Published?:
Published
Last Modified:
16 Sep 2023 00:38