Amyloid deposition as the central event in the aetiology of Alzheimer's disease

Hardy, J and Allsop, D (1991) Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends in Pharmacological Sciences, 12 (10). pp. 383-388. ISSN 0165-6147

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Abstract

While there may be many causes of Alzheimer's disease (AD), the same pathological sequence of events, described here by John Hardy and David Allsop, is likely to occur in all cases. The recent discovery of a pathogenic mutation in the beta-amyloid precursor protein (APP) gene on chromosome 21 suggests that APP Mismetabolism and beta-amyloid deposition are the primary events in the disease process. The occurrence of AD in Down syndrome is consistent with this hypothesis. The pathological cascade for the disease process is most likely to be: beta-amyloid deposition----tau phosphorylation and tangle formation----neuronal death. The development of a biochemical understanding of this pathological cascade will facilitate rational design of drugs to intervene in this process.

Item Type:
Journal Article
Journal or Publication Title:
Trends in Pharmacological Sciences
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3000/3005
Subjects:
?? alzheimer diseaseamyloidamyloid beta-protein precursoranimalscell deathhumansneurofibrillary tanglestoxicologypharmacology ??
ID Code:
50850
Deposited By:
Deposited On:
08 Nov 2011 10:26
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jul 2024 12:26