Ikeda, S and Tokuda, T and Yanagisawa, N and Kametani, F and Ohshima, T and Allsop, D (1994) Variability of β-amyloid protein deposited lesions in Down's syndrome brains. The Tohoku Journal of Experimental Medicine, 174 (3). pp. 189-198. ISSN 0040-8727
Full text not available from this repository.Abstract
An immunohistochemical study was carried out on the brains of 7 adult Down's syndrome cases (ages 31 to 62) using antibodies to beta-protein, beta-amyloid protein precursor and tau-protein. Variable forms of beta-protein deposited lesions (including senile plaques and cerebrovascular amyloidosis) were observed in extensive areas of the neocortex of all cases and coexistence of both beta-protein amyloid fibrils and beta-amyloid protein precursors was also seen in some of these lesions. Moreover, 3 cases at an advanced stage showed a few plaque-like lesions with beta-protein immunoreactivity in the white matter. The following temporal morphological change is suggested for the pathogenesis of Alzheimer's disease: senile plaque undergo sequential structural changes and beta-protein amyloid deposits in the form of "early plaque" precede the development of tau-immunoreactive neurofibrillary degeneration.