Tabner, Brian and Turnbull, Stuart and Fullwood, N J and German, Matthew and Allsop, D (2005) The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases? Biochemical Society Transactions, 33 (4). pp. 548-550. ISSN 0300-5127
Full text not available from this repository.Abstract
By means of an ESR spin-trapping method, we have shown that A beta (amyloid beta), alpha-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.