Donnell, Peter and Baigent, Stephen A. and Banaji, Murad (2009) Monotone dynamics of two cells dynamically coupled by a voltage-dependent gap junction. Journal of Theoretical Biology, 261 (1). pp. 120-125. ISSN 0022-5193
Full text not available from this repository.Abstract
We introduce and analyse a simple model for two non-excitable cells that are dynamically coupled by a gap junction, a plaque of aqueous channels that electrically couple the cells. The gap junction channels have a low and high conductance state, and the transition rates between these states are voltage-dependent. We show that the number and stability of steady states of the system has a simple relationship with the determinant of the Jacobian matrix. For the case that channel opening rates decrease with increasing trans-junctional voltage, and closing rates increase with increasing trans-junctional voltage, we show that the system is monotone, with tridiagonal Jacobian matrix, and hence every initial condition evolves to a steady state, but that there may be multiple steady states.