Banaji, Murad and Tachtsidis, Ilias and Delpy, David and Baigent, Stephen (2005) A physiological model of cerebral blood flow control. Mathematical Biosciences, 194 (2). pp. 125-173. ISSN 0025-5564
Full text not available from this repository.Abstract
The construction of a computational model of the human brain circulation is described. We combine an existing model of the biophysics of the circulatory system, a basic model of brain metabolic biochemistry, and a model of the functioning of vascular smooth muscle (VSM) into a single model. This represents a first attempt to understand how the numerous different feedback pathways by which cerebral blood flow is controlled interact with each other. The present work comprises the following: Descriptions of the physiology underlying the model; general comments on the processes by which this physiology is translated into mathematics; comments on parameter setting; and some simulation results. The simulations presented are preliminary, but show qualitative agreement between model behaviour and experimental results.