Redirection of cellular cytotoxicity: a two step approach using recombinant single-chain Fv molecules.

George, A. J. T. and Titus, J. A. and Jost, C. R. and Kurucz, I. and Perez, P. and Andrew, S. M. and Nicholls, P. J. and Huston, J. S. and Segal, D. M. (1995) Redirection of cellular cytotoxicity: a two step approach using recombinant single-chain Fv molecules. Cell Biochemistry and Biophysics, 26 (3). pp. 153-165. ISSN 1085-9195

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Abstract

In this article the authors discuss an indirect system for redirecting cellular cytotoxicity, which utilizes a “universal” bispecific antibody to redirect T-cells to kill cells targeted with single-chain Fv (sFv) fusion proteins that carry a peptide tag recognized by the bispecific antibody. This approach has a number of theoretical advantages in the immunotherapy of cancer.

Item Type:
Journal Article
Journal or Publication Title:
Cell Biochemistry and Biophysics
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1303
Subjects:
?? bispecific antibody - single-chain fv - redirected cellular cytotoxicity - immunotherapybiochemistrycell biologybiophysicsge environmental sciences ??
ID Code:
22265
Deposited By:
Deposited On:
06 Feb 2009 15:23
Refereed?:
No
Published?:
Published
Last Modified:
15 Jul 2024 10:06