George, A. J. T. and Titus, J. A. and Jost, C. R. and Kurucz, I. and Perez, P. and Andrew, S. M. and Nicholls, P. J. and Huston, J. S. and Segal, D. M. (1995) Redirection of cellular cytotoxicity: a two step approach using recombinant single-chain Fv molecules. Cell Biochemistry and Biophysics, 26 (3). pp. 153-165. ISSN 1085-9195
Full text not available from this repository.Abstract
In this article the authors discuss an indirect system for redirecting cellular cytotoxicity, which utilizes a “universal” bispecific antibody to redirect T-cells to kill cells targeted with single-chain Fv (sFv) fusion proteins that carry a peptide tag recognized by the bispecific antibody. This approach has a number of theoretical advantages in the immunotherapy of cancer.