Design, synthesis and Photodynamic antimicrobial activity of ruthenium trischelate diimine complexes

Donnelly, R. F. and Fletcher, N. C. and McCague, P. J. and Donnelly, J. and McCarron, P. A. and Tunney, M. M. (2007) Design, synthesis and Photodynamic antimicrobial activity of ruthenium trischelate diimine complexes. Letters in Drug Design and Discovery, 4 (3). pp. 175-179. ISSN 1570-1808

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Abstract

In this study, we describe, for the first time, the synthesis and photophysical and microbiological investigation of ruthenium trischelate diimine complexes designed so as to possess properties specifically suited for use in Photodynamic antimicrobial chemotherapy (PACT). Of the three compounds investigated, one ([Ru(dmob)3]Cl2) has demonstrated considerable promise as a photosensitiser for use in PACT. As a result, this compound is now the subject of comprehensive chemical, toxicological and formulation studies.

Item Type:
Journal Article
Journal or Publication Title:
Letters in Drug Design and Discovery
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1313
Subjects:
?? photodynamic antimicrobial chemotherapyrutheniummolecular medicinepharmaceutical sciencedrug discovery ??
ID Code:
203429
Deposited By:
Deposited On:
13 Sep 2023 14:35
Refereed?:
Yes
Published?:
Published
Last Modified:
16 Jul 2024 00:09