Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Thietane 1,1-Dioxides

Laidlaw, Gillian and Franckevicius, Vilius (2022) Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Thietane 1,1-Dioxides. Organic Letters, 24 (1). pp. 400-405. ISSN 1523-7060

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Abstract

A palladium-catalyzed decarboxylative asymmetric allylic alkylation of thietane 1,1-dioxides via linear enolate intermediates from racemic starting materials has been developed. This process installs an α-sulfonyl tetrasubstituted stereogenic center with high enantioselectivity. The potential to transform the alkylated products to novel types of enantioenriched spirocycles for medicinal chemistry applications has also been demonstrated.

Item Type:

Journal Article

Journal or Publication Title:

Organic Letters

Additional Information:

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.orglett.1c04075

Uncontrolled Keywords:

/dk/atira/pure/subjectarea/asjc/1300/1303

Subjects:

?? biochemistryorganic chemistryphysical and theoretical chemistry ??

ID Code:

164200

Deposited By:

ep_importer_pure

Deposited On:

10 Jan 2022 11:50

Refereed?:

Yes

Published?:

Published

Last Modified:

27 Feb 2024 01:47

URI:

https://eprints.lancs.ac.uk/id/eprint/164200