An alkyne hydrosilylation-Hiyama coupling approach to highly functionalised 1,3-dienes

McAdam, C.A. and McLaughlin, M.G. and Cook, M.J. (2015) An alkyne hydrosilylation-Hiyama coupling approach to highly functionalised 1,3-dienes. Organic Chemistry Frontiers, 2 (5). pp. 510-514.

Abstract

A high yielding and robust protocol for the stereodefined synthesis of 1,3-dienes has been established through a hydrosilylation–Hiyama coupling strategy. In all cases the products were formed as single E,E isomers and conditions are tolerant of a wide range of functional groups not compatible with other methods.