Physics of selective conduction and point mutation in biological ion channels

Gibby, William A. T. and Barabash, Miraslau L. and Guardiani, Carlo and Luchinsky, Dmitry G. and McClintock, Peter V. E. (2021) Physics of selective conduction and point mutation in biological ion channels. Physical review letters, 126 (21): 218102. ISSN 1079-7114

[thumbnail of Supplementarty Material]
Text (Supplementarty Material)
PRLSI.pdf - Accepted Version
Available under License Creative Commons Attribution.

Download (3MB)
[thumbnail of PRLPaper]
Text (PRLPaper)
PRLPaper.pdf - Accepted Version
Available under License Creative Commons Attribution.

Download (1MB)

Abstract

We introduce a statistical and linear response theory of selective conduction in biological ion channels with multiple binding sites and possible point mutation. We derive an effective grand canonical ensemble and generalised Einstein relations for the selectivity filter, assuming strongly coordinated ionic motion, and allowing for ionic Coulomb blockade. The theory agrees well with data from the KcsA K+ channel and a mutant. We show that the Eisenman relations for thermodynamic selectivity follow from the condition for fast conduction and find that maximum conduction requires the binding sites to be nearly identical

Item Type:
Journal Article
Journal or Publication Title:
Physical review letters
Additional Information:
© 2022 American Physical Society
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3100/3100
Subjects:
?? general physics and astronomyphysics and astronomy(all) ??
ID Code:
154188
Deposited By:
Deposited On:
26 Apr 2021 10:25
Refereed?:
Yes
Published?:
Published
Last Modified:
04 Aug 2024 23:53