NADH regeneration : a case study of Pt-catalyzed NAD+ reduction with H2

Saba, Tony and Li, Jianwei and Burnett, Joseph W.H. and Howe, Russell F. and Kechagiopoulos, Panagiotis N. and Wang, Xiaodong (2021) NADH regeneration : a case study of Pt-catalyzed NAD+ reduction with H2. ACS Catalysis, 11 (1). 283–289. ISSN 2155-5435

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Abstract

This study shows the importance of resolving catalytic performance in the regeneration of the reduced form of nicotinamide adenine dinucleotide (NADH) through activity measurements based on NAD+ conversion and the closure of mass balance via by-product quantification. This approach is applied to assess the performance of supported platinum catalysts with varying points of zero charge, utilizing H2 as a reductant. It was found that Pt/SiO2, which exhibits a net negative charge under the reaction conditions, outperforms the neutral Pt/C and positively charged Pt/MgO due to the favorable electrostatic attraction between the catalyst surface and positively charged (+1) nicotinamide ring. NMR spectroscopy identifies side-products formed during NAD+ hydrogenation.

Item Type:

Journal Article

Journal or Publication Title:

ACS Catalysis

Additional Information:

This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acscatal.0c04360

Uncontrolled Keywords:

/dk/atira/pure/subjectarea/asjc/1500/1503

Subjects:

?? catalysis ??

Departments:

Faculty of Science and Technology > Engineering

ID Code:

150045

Deposited By:

ep_importer_pure

Deposited On:

17 Dec 2020 10:06

Refereed?:

Yes

Published?:

Published

Last Modified:

30 Nov 2024 01:04

URI:

https://eprints.lancs.ac.uk/id/eprint/150045