NADH regeneration:a case study of Pt-catalyzed NAD+ reduction with H2

Saba, Tony and Li, Jianwei and Burnett, Joseph W.H. and Howe, Russell F. and Kechagiopoulos, Panagiotis N. and Wang, Xiaodong (2021) NADH regeneration:a case study of Pt-catalyzed NAD+ reduction with H2. ACS Catalysis, 11 (1). 283–289. ISSN 2155-5435

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This study shows the importance of resolving catalytic performance in the regeneration of the reduced form of nicotinamide adenine dinucleotide (NADH) through activity measurements based on NAD+ conversion and the closure of mass balance via by-product quantification. This approach is applied to assess the performance of supported platinum catalysts with varying points of zero charge, utilizing H2 as a reductant. It was found that Pt/SiO2, which exhibits a net negative charge under the reaction conditions, outperforms the neutral Pt/C and positively charged Pt/MgO due to the favorable electrostatic attraction between the catalyst surface and positively charged (+1) nicotinamide ring. NMR spectroscopy identifies side-products formed during NAD+ hydrogenation.

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Journal Article
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ACS Catalysis
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This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
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17 Dec 2020 10:06
Last Modified:
26 Sep 2023 00:21