Creating a framework for conducting randomized clinical trials during disease outbreaks

Dean, N.E. and Gsell, P.-S. and Brookmeyer, R. and Crawford, F.W. and Donnelly, C.A. and Ellenberg, S.S. and Fleming, T.R. and Halloran, E.M. and Horby, P. and Jaki, T. and Krause, P.R. and Longini, I.M. and Mulangu, S. and Muyembe-Tamfum, J.-J. and Nason, M.C. and Smith, P.G. and Wang, R. and Henao-Restrepo, A.M. and De Gruttola, V. (2020) Creating a framework for conducting randomized clinical trials during disease outbreaks. New England Journal of Medicine, 382 (14). pp. 1366-1369. ISSN 0028-4793

Abstract

As in the ongoing Covid-19 pandemic, global outbreaks of infectious illnesses often develop quickly and resolve in unpredictable ways. In this report, strategies to develop high-quality evidence to guide the development of new therapies are proposed.