Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR

Lau, Sophie and Griffin, John and Hughes, Eleri and Middleton, David (2019) Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR. Chemical Communications, 55 (88). pp. 13287-13290. ISSN 1359-7345

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Abstract

NMR measurements of 19F chemical shift anisotropy and 1H-19F dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density lipoprotein (rHDL) nanoparticles, a drug delivery system under clinical investigation.